RECRUITING

Modulating Exercise Dosage to Improve Concussion Recovery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.

Official Title

Modulating Exercise Dosage to Improve Concussion Recovery: a Randomized Clinical Trial

Quick Facts

Study Start:2022-08-05
Study Completion:2027-02-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05434130

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:13 Years to 18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * 13-18 years of age
  2. * Post-Concussion Symptom Scale (PCSS) score \>10 to ensure participants are not recovered by enrollment
  3. * Concussion diagnosis by a sports medicine physician
  1. * Pre-existing neurological disorders
  2. * Exercise contraindications
  3. * Concussion \<6 months before enrollment (excluding the current injury)

Contacts and Locations

Study Contact

David R Howell, PhD
CONTACT
7207771502
ConcussionResearch@cuanschutz.edu
Kelsie Richardson, MS
CONTACT
7207771502
ConcussionResearch@cuanschutz.edu

Principal Investigator

David R Howell, PhD
PRINCIPAL_INVESTIGATOR
University of Colorado Denver | Anschutz

Study Locations (Sites)

University of Colorado Denver
Aurora, Colorado, 80045
United States
Boston Children's Hospital
Boston, Massachusetts, 02115
United States
Spaulding Rehabilitation Hospital
Cambridge, Massachusetts, 02138
United States

Collaborators and Investigators

Sponsor: University of Colorado, Denver

  • David R Howell, PhD, PRINCIPAL_INVESTIGATOR, University of Colorado Denver | Anschutz

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-08-05
Study Completion Date2027-02-01

Study Record Updates

Study Start Date2022-08-05
Study Completion Date2027-02-01

Terms related to this study

Keywords Provided by Researchers

  • intervention
  • mild traumatic brain injury

Additional Relevant MeSH Terms

  • Concussion, Brain
  • Treatment
  • Aerobic Exercise
  • Inflammation
  • Depression, Anxiety