RECRUITING

Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

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Conditions

DepressionPositive AffectTheta Burst Stimulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.

Official Title

Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

Quick Facts

Study Start:2022-06-17
Study Completion:2025-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05436379

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 26 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Current Diagnostic and Statistical Manual (DSM-5) Depressive Disorder
  1. * Bipolar disorder (lifetime)
  2. * Obsessive-compulsive disorder (lifetime)
  3. * History of psychosis
  4. * Daily use of nicotine
  5. * Past-month use of cocaine, amphetamines, Methyl enedioxy methamphetamine (MDMA), Phencyclidine (PCP), Ketamine, or gamma-hydroxybutyrate (GHB)
  6. * Past 6 month substance use disorder
  7. * Binge drinking (using NIAAA criteria) within the past week, alcohol use in the past 12 hours
  8. * Neurological disorders: Epilepsy, Parkinson's Disease, brain tumor, brain injury, stroke
  9. * History of head trauma with a loss of consciousness (e.g., concussion)
  10. * History of seizures
  11. * MRI contraindications: body shape/size too large to fit in scanner, claustrophobia, and ferromagnetic metal in the body
  12. * Pregnancy
  13. * Current use of Clozapine, Bupropion, or prescription stimulants
  14. * Current use of benzodiazepines or mood stabilizers
  15. * Body shape/size too large to fit in MRI scanner
  16. * Claustrophobia
  17. * Metal in the head or ferromagnetic metal in the rest of the body
  18. * Implanted medical devices
  19. * High-risk suicidality

Contacts and Locations

Study Contact

Ashley Pogue, B.A.
CONTACT
4123549297
pogueam@upmc.edu
Study Coordinator
CONTACT
TMS_Study@pitt.edu

Principal Investigator

Erika E Forbes, Ph.D
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

The University of Pittsburgh, Department of Psychiatry
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: Erika Forbes

  • Erika E Forbes, Ph.D, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-06-17
Study Completion Date2025-06-30

Study Record Updates

Study Start Date2022-06-17
Study Completion Date2025-06-30

Terms related to this study

Keywords Provided by Researchers

  • Positive Affect
  • Theta Burst Stimulation

Additional Relevant MeSH Terms

  • Depression