Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

Description

The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.

Conditions

Depression

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Study Overview

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Study Details

Study overview

The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.

Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

Condition
Depression
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

The University of Pittsburgh, Department of Psychiatry, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Current Diagnostic and Statistical Manual (DSM-5) Depressive Disorder
  • * Bipolar disorder (lifetime)
  • * Obsessive-compulsive disorder (lifetime)
  • * History of psychosis
  • * Daily use of nicotine
  • * Past-month use of cocaine, amphetamines, Methyl enedioxy methamphetamine (MDMA), Phencyclidine (PCP), Ketamine, or gamma-hydroxybutyrate (GHB)
  • * Past 6 month substance use disorder
  • * Binge drinking (using NIAAA criteria) within the past week, alcohol use in the past 12 hours
  • * Neurological disorders: Epilepsy, Parkinson's Disease, brain tumor, brain injury, stroke
  • * History of head trauma with a loss of consciousness (e.g., concussion)
  • * History of seizures
  • * MRI contraindications: body shape/size too large to fit in scanner, claustrophobia, and ferromagnetic metal in the body
  • * Pregnancy
  • * Current use of Clozapine, Bupropion, or prescription stimulants
  • * Current use of benzodiazepines or mood stabilizers
  • * Body shape/size too large to fit in MRI scanner
  • * Claustrophobia
  • * Metal in the head or ferromagnetic metal in the rest of the body
  • * Implanted medical devices
  • * High-risk suicidality

Ages Eligible for Study

18 Years to 26 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Erika Forbes,

Erika E Forbes, Ph.D, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2025-06-30