RECRUITING

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

Conditions

Major Depressive Disorder Suicidal Ideas Suicide, Attempted MDD Depression Depression, Teen Depression and Suicide Depression in Adolescence Suicide

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depressive and suicidal behavior and on biomarkers (e.g. miRNA) for these disorders.

Official Title

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

Quick Facts

Study Start:2022-10-01

Study Completion:2027-06-30

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05437588

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:10 Years to 24 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:CHILD, ADULT

Inclusion Criteria	Exclusion Criteria
1. Physically healthy 2. willing and able to provide informed consent (if under 18 also parent or guardian consent) 1. A definite diagnosis of DSM-5 2. a Children's Depression Rating Scale-Revised (CDRS-R) score \>=30. Suicidal ideation participants: Columbia Suicide Severity Rating Scale (C-SSRS) score \>=4 rated over the last two weeks. 1. Participants will have had an attempt in the previous two weeks that is serious enough to require medical attention and shows evidence of at least a medium level of intent on the Suicide Intent Scale. 1. No history of any major mental illness (excluding specific phobia) or substance use disorder.	*

Inclusion Criteria

Exclusion Criteria

1. Physically healthy
2. willing and able to provide informed consent (if under 18 also parent or guardian consent)
1. A definite diagnosis of DSM-5
2. a Children's Depression Rating Scale-Revised (CDRS-R) score \>=30. Suicidal ideation participants: Columbia Suicide Severity Rating Scale (C-SSRS) score \>=4 rated over the last two weeks.
1. Participants will have had an attempt in the previous two weeks that is serious enough to require medical attention and shows evidence of at least a medium level of intent on the Suicide Intent Scale.
1. No history of any major mental illness (excluding specific phobia) or substance use disorder.

Contacts and Locations

Study Contact

Allison Stewart, MA

CONTACT

256-551-4431

allisonstewart@uabmc.edu

Study Locations (Sites)

University of Alabama at Birmingham

Birmingham, Alabama, 35233

United States

UAB Huntsville Regional Medical Campus

Huntsville, Alabama, 35294

United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-10-01

Study Completion Date2027-06-30

Study Record Updates

Study Start Date2022-10-01

Study Completion Date2027-06-30

Terms related to this study

Additional Relevant MeSH Terms

Major Depressive Disorder
Suicidal Ideas
Suicide, Attempted
MDD
Depression
Depression, Teen
Depression and Suicide
Depression in Adolescence
Suicide