Decoding and Modulating Affective Brain States

Description

Generating personalized brain signatures of negative emotion along with personalized brain stimulation protocols to disrupt these patterns. We plan to use fMRI and muscle activity data to determine negative affect maps for each participant. We will then try a variety of patterned repetitive transcranial magnetic stimulation sequences while recording fMRI which will be the basis of two sessions of 3-day individualized brain stimulation designed to reduce negative affect.

Conditions

Rumination, Major Depressive Disorder, Anxiety

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Study Overview

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Study Details

Study overview

Generating personalized brain signatures of negative emotion along with personalized brain stimulation protocols to disrupt these patterns. We plan to use fMRI and muscle activity data to determine negative affect maps for each participant. We will then try a variety of patterned repetitive transcranial magnetic stimulation sequences while recording fMRI which will be the basis of two sessions of 3-day individualized brain stimulation designed to reduce negative affect.

Decoding and Modulating Affective Brain States

Decoding and Modulating Affective Brain States

Condition
Rumination
Intervention / Treatment

-

Contacts and Locations

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. 18-65 years old
  • 2. Right-handed
  • 3. Patient Health Questionnaire (PHQ-9 score) = or \> than 10
  • 4. Comprehension of instructions in the English language.
  • 5. Capacity to provide informed consent and follow study procedures.
  • 6. Availability for the duration of the study.
  • 1. Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychotic disorder
  • 2. Recent use of psychoactive medications or substances as determined by investigators
  • 3. History of neurological disorder or traumatic brain injury (other than mild)
  • 4. Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data
  • 5. Unable to receive or tolerate TMS
  • 6. Implanted devices, such as an aneurysm clip or cardiac pacemaker
  • 7. History of stroke, epilepsy, or brain scarring
  • 8. Pregnant, nursing, or trying to become pregnant (self-attestation alone)
  • 9. Otherwise determined by investigator to be unfit for study

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pennsylvania,

Desmond Oathes, PhD, PRINCIPAL_INVESTIGATOR, Assistant Professor of Psychiatry

Study Record Dates

2028-12-01