COMPLETED

Acute Recording of Stereotyped High-Frequency Oscillations

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting.

Official Title

Acute Recording of Stereotyped High-Frequency Oscillations With a Closed-Loop Brain Interchange System in Drug-Resistant Epilepsy

Quick Facts

Study Start:2021-09-01
Study Completion:2025-08-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05439655

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:3 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * patients with medically refractory epilepsy, who have been deemed appropriate candidates for intracranial EEG monitoring
  2. * Adult men and women (18≤ age \<70 years)
  3. * children (3≤ age \<18 years)
  4. * includes women and minorities
  1. * Subjects will be excluded if their condition makes them unable to continue with recordings.

Contacts and Locations

Study Locations (Sites)

Mayo Clinic
Rochester, Minnesota, 55905
United States
Baylor College of Medicine
Houston, Texas, 77030-3498
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-09-01
Study Completion Date2025-08-04

Study Record Updates

Study Start Date2021-09-01
Study Completion Date2025-08-04

Terms related to this study

Keywords Provided by Researchers

  • Neuromodulation
  • HFO
  • Epilepsy
  • Machine Learning
  • Closed-Loop

Additional Relevant MeSH Terms

  • Epilepsy