Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day Start

Description

This is a prospective clinical research study to test the effectiveness of the Levonorgestrel (LNG) 52 mg Intrauterine Device (IUD) for emergency contraception (EC) and same-day start use that will enroll people receiving care at Planned Parenthood affiliates across the U.S. Our prior work demonstrated efficacy (shows that it works in an ideal setting) for the LNG 52 mg IUD for these uses and this study will test effectiveness (how well it works in the real world) in a larger, heterogenous population in a usual care setting where participants select their method and are not randomly assigned to it. The study population will include people initiating an LNG 52 mg IUD and meet inclusion and exclusion criteria at 8 Planned Parenthood affiliates nationwide. Planned Parenthood Federation of America was the first major healthcare organization to change its practice to incorporate the changes we are studying here. As such, all study participants will be offered the opportunity to choose the interventional IUD at the site they visit. The primary outcome is pregnancy status one month after LNG IUD placement by home urine pregnancy test or clinical record review. Participant follow up concludes one month after enrollment. The purpose of this study is to demonstrate reproducibility of earlier findings in a more heterogenous population. As such, IUD placement is not a study procedure but a component of clinical care. The study interventions only involve study participation and provision of data around the use of the levonorgestrel 52 mg IUD for EC or same day start.

Conditions

Contraception

Study Overview

Study Details

Study overview

This is a prospective clinical research study to test the effectiveness of the Levonorgestrel (LNG) 52 mg Intrauterine Device (IUD) for emergency contraception (EC) and same-day start use that will enroll people receiving care at Planned Parenthood affiliates across the U.S. Our prior work demonstrated efficacy (shows that it works in an ideal setting) for the LNG 52 mg IUD for these uses and this study will test effectiveness (how well it works in the real world) in a larger, heterogenous population in a usual care setting where participants select their method and are not randomly assigned to it. The study population will include people initiating an LNG 52 mg IUD and meet inclusion and exclusion criteria at 8 Planned Parenthood affiliates nationwide. Planned Parenthood Federation of America was the first major healthcare organization to change its practice to incorporate the changes we are studying here. As such, all study participants will be offered the opportunity to choose the interventional IUD at the site they visit. The primary outcome is pregnancy status one month after LNG IUD placement by home urine pregnancy test or clinical record review. Participant follow up concludes one month after enrollment. The purpose of this study is to demonstrate reproducibility of earlier findings in a more heterogenous population. As such, IUD placement is not a study procedure but a component of clinical care. The study interventions only involve study participation and provision of data around the use of the levonorgestrel 52 mg IUD for EC or same day start.

Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day Start

Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day Start

Condition
Contraception
Intervention / Treatment

-

Contacts and Locations

San Jose

Planned Parenthood Mar Monte, San Jose, California, United States, 95126

Denver

Planned Parenthood of the Rocky Mountains, Denver, Colorado, United States, 80207

Chicago

Planned Parenthood Illinoi, Chicago, Illinois, United States, 60603

Boston

Planned Parenthood League of Massachusetts, Boston, Massachusetts, United States, 02215

Saint Paul

Planned Parenthood North Central States, Saint Paul, Minnesota, United States, 55114

Portland

Planned Parenthood Columbia Willamette, Portland, Oregon, United States, 97212

Salt Lake City

Planned Parenthood Association of Utah, Salt Lake City, Utah, United States, 84102

Seattle

Planned Parenthood Great Northwest Hawaii, Alaska, Indiana, Kentucky, Seattle, Washington, United States, 98122

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Meet clinic eligibility for IUD placement
  • * Have a LNG 52 mg IUD placed for either emergency contraception (had unprotected intercourse in the last 5 days) OR Same-day start, \>7 days since the onset of last menstrual period and have no report of unprotected intercourse in the last 5 days
  • * Negative high sensitivity urine pregnancy test prior to IUD placement.
  • * No known contraindications to the LNG 52 mg IUD per the CDC Medical Eligibility Criteria for Contraceptive Use 2016
  • * Have had penile-vaginal intercourse at least once since their last menstrual period. If last menstrual period is unknown or irregular, then have had penile-vaginal intercourse at least once in the last month.
  • * Fluent in English or Spanish
  • * Working Cell Phone number that receives text messages
  • * Willing to comply with the study requirements including providing 1-month follow up data including a urine pregnancy test result one month after IUD placement
  • * Current pregnancy
  • * Currently Breastfeeding
  • * Current use of permanent contraception (has had a hysterectomy, tubal permanent contraception, or partner with a vasectomy in the last month)
  • * Use of any contraceptive pills, patches, vaginal rings or any contraceptive implant or IUD use in the last 4 weeks
  • * Use of oral emergency contraception in last 5 days
  • * Vaginal bleeding of unknown etiology
  • * Use of injectable hormonal contraceptive (Depo-Provera) in the last 6 months
  • * Planned use of any non-contraceptive estrogen, progesterone, or testosterone
  • * Acute cervicitis
  • * Known abnormalities of the uterus that distort the uterine cavity
  • * Ended pregnancy at or under 20 weeks gestational age within the last 2 weeks
  • * Ended pregnancy over 20 weeks gestational age within the last 6 weeks

Ages Eligible for Study

16 Years to 35 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Utah,

David Turok, MD, MPH, PRINCIPAL_INVESTIGATOR, University of Utah

Study Record Dates

2027-07-31