Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles

Description

The proposed project seeks to elucidate memory processes and consolidation during sleep by leveraging the unique capability of direct recordings from the human brain at multiple levels of resolution-single neurons, localized neuronal assemblies, intracranial local field potentials-during rich behavioral tasks with real-life narratives and extracting neural features that relate to different aspects of episodic experience. The investigators will further probe causal mechanisms of consolidation by application of auditory and electrical stimulations during sleep and its effect on modulating memory processes.

Conditions

Memory, Delayed

Study Overview

Study Details

Study overview

The proposed project seeks to elucidate memory processes and consolidation during sleep by leveraging the unique capability of direct recordings from the human brain at multiple levels of resolution-single neurons, localized neuronal assemblies, intracranial local field potentials-during rich behavioral tasks with real-life narratives and extracting neural features that relate to different aspects of episodic experience. The investigators will further probe causal mechanisms of consolidation by application of auditory and electrical stimulations during sleep and its effect on modulating memory processes.

Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles

Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles

Condition
Memory, Delayed
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of California Los Angeles, Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * All epilepsy patients between the ages of 18 and 65 who undergo depth electrode placement for clinical purposes
  • * Eligibility is determined by the epilepsy surgery team (based on neuropsychological testing and on psychiatric evaluation)
  • * Willing to provide informed consent and participate the study
  • * Neurological or psychiatric issues, other than epilepsy, that would put the patient at risk
  • * Patient is younger than 18 or older than 65 years of age
  • * Unwilling to provide informed consent

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Study Record Dates

2026-08-31