Multiomic Diagnostics in Youth With Psychosis

Description

Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic symptoms or schizophrenia. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve our ability to identify the cause of psychosis and impact care. The investigator also hopes to identify new genetic and/or autoimmune causes of psychosis that may inform new treatment for future patients.

Conditions

Psychosis

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Study Overview

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Study Details

Study overview

Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic symptoms or schizophrenia. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve our ability to identify the cause of psychosis and impact care. The investigator also hopes to identify new genetic and/or autoimmune causes of psychosis that may inform new treatment for future patients.

Multiomic Diagnostics in Child and Adolescent Psychosis

Multiomic Diagnostics in Youth With Psychosis

Condition
Psychosis
Intervention / Treatment

-

Contacts and Locations

San Diego

Rady Children's Hospital San Diego, San Diego, California, United States, 92123

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Child/adolescent admitted to the Rady Children's CAPS with symptoms of first break psychosis
  • 2. Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed genetically related to a patient participant.
  • 1. Already received any prior whole genome sequencing or exome sequencing.
  • 2. Unable to approach the family or patient for enrollment.
  • 3. Unable to obtain informed consent.
  • 4. Family members are ineligible for participation in this study if:
  • 1. They are known to not be genetically related to the child/adolescent patient participant
  • 2. They are a member of a protected research population

Ages Eligible for Study

7 Years to 17 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Rady Pediatric Genomics & Systems Medicine Institute,

Aaron Besterman, MD, PRINCIPAL_INVESTIGATOR, Rady Pediatric Genomics & Systems Medicine Institute

Study Record Dates

2026-08