Association Between Body Composition and Pain in Spinal Cord Injury

Description

The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and explore the influence of body composition on these responses, in individuals with chronic spinal cord injury

Conditions

Pain, Inflammatory Response

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Study Overview

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Study Details

Study overview

The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and explore the influence of body composition on these responses, in individuals with chronic spinal cord injury

Association Among Body Composition, Chronic Pain, Evoked Pain Sensitivity, and Adiposity-related Systemic Inflammation in Individuals With Spinal Cord Injury

Association Between Body Composition and Pain in Spinal Cord Injury

Condition
Pain
Intervention / Treatment

-

Contacts and Locations

Coral Gables

University of Miami, Coral Gables, Florida, United States, 33146

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-65 years
  • * SCI occurring at least 2 years prior to study entry
  • * Neurological level of injury (LOI) between C4 and L2
  • * American Spinal Injury Association Impairment Scale (AIS) A-D
  • * English-speaking.
  • * Cognitive dysfunction that limits ability to adequately understand the risks of the study or are otherwise unable to consent
  • * Health conditions associated with chronic systemic inflammation unrelated to weight or adiposity (e.g., systemic autoimmune diseases, recurrent or active urinary tract infection, pressure injury \> Stage 2)
  • * Conditions that preclude measurement of body composition by dual-energy x-ray absorptiometry (DXA; e.g., lower limb contracture \> 15 degrees)
  • * Inability to obtain free-flowing blood from a superficial forearm or hand vein
  • * Pregnant women
  • * Prisoners

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Miami,

Elizabeth Felix, PhD, PRINCIPAL_INVESTIGATOR, University of Miami

Study Record Dates

2027-08-31