Protein Sources Urinary Stone Risk

Description

Prior studies have shown that the source of dietary protein can have a significant impact on urinary stone risk. However, whey and plant protein isolates have not been compared. This is an important distinction as protein supplements fortified foods are increasingly popular. Herein, we seek to investigate the effect of different protein supplements, in an otherwise identical diet, on urinary stone risk.

Conditions

Kidney Stone Prevention

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Study Overview

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Study Details

Study overview

Prior studies have shown that the source of dietary protein can have a significant impact on urinary stone risk. However, whey and plant protein isolates have not been compared. This is an important distinction as protein supplements fortified foods are increasingly popular. Herein, we seek to investigate the effect of different protein supplements, in an otherwise identical diet, on urinary stone risk.

The Effect of Protein Sources on Urinary Stone Risk

Protein Sources Urinary Stone Risk

Condition
Kidney Stone Prevention
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Washington University, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Willing and able to complete the study
  • 2. Healthy with no personal or family history of kidney stones
  • 1. Allergy to any protein isolates or menu items used in the study
  • 2. History of calcium oxalate, cysteine, uric acid, or infection stones
  • 3. Disorders of absorption: Celiac disease, Irritable Bowel Disease, chronic diarrhea, short gut
  • 4. Systemic predisposition to stones: gout, congenital hyperuricemia, chronic diarrhea, insulin resistance, neoplastic disorders, hyperparathyroidism or renal tubular acidosis
  • 5. Women who are currently pregnant or planning pregnancy within 2 years
  • 6. Renal transplant recipient
  • 7. Bedridden study participants (ECOG ≥ 3)
  • 8. Uncorrected anatomical obstruction of the urinary tract
  • 9. History of recurrent urinary tract infections (\> 3 urinary tract infections/year proven by urine culture)
  • 10. Exclusions due to medication use:
  • 1. Chronic use of lithium
  • 2. Long-term glucocorticoid use (\> 7.5 mg prednisone daily for \> 30 days prior to enrollment)
  • 3. Intake of narcotic medication on a daily basis for \>30 days prior to enrollment
  • 4. Supplemental Vitamin C (\> 1 g daily)
  • 5. Carbonic anhydrase inhibitors (acetazolamide, topiramate, zonisamide)
  • 6. high dose calcium supplementation (\> 1,200 mg daily)
  • 7. Medications that may crystallize in the urine (guaifenesin, sulfonamides, triamterene, and the protease inhibitors indinavir and nelfinavir).
  • 11. Non-English Speakers
  • 12. History of Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
  • 13. Anatomical urologic abnormalities including ileal conduits, horseshoe kidney, megaureter or solitary kidney
  • 14. Psychiatric conditions impairing compliance with the study
  • 15. Vulnerable population (prisoner and/or cognitive impairment that the investigator feels will impact participant's ability to complete study activities)

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Washington University School of Medicine,

Study Record Dates

2023-07-30