SV2A in Older Adults

Description

The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using \[11C\]UCB-J PET imaging.

Conditions

Cannabis Use

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Study Overview

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Study Details

Study overview

The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using \[11C\]UCB-J PET imaging.

Effect of Cannabis Use on Synaptic Density in Older Adults

SV2A in Older Adults

Condition
Cannabis Use
Intervention / Treatment

-

Contacts and Locations

New Haven

Connecticut Mental Health Center, New Haven, Connecticut, United States, 06519

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Able to provide informed consent
  • * Male or female, aged ≥50 years
  • * No history of significant medical or neurological disease
  • * BMI ≤ 50
  • * If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans
  • * Women with a positive pregnancy test or women who are lactating
  • * Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
  • * History of a bleeding disorder or are currently taking anticoagulants
  • * Subjects who have donated blood within 8 weeks of the present study

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Yale University,

Rajiv Radhakrishnan, MBBS, MD, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2025-09-30