To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

Description

This is a randomized, open-label study of Serplulimab plus chemotherapy (Carboplatin-Etoposide) in comparison with Atezolizumab plus chemotherapy in previously untreated US patients with ES-SCLC. Subjects in this study will be randomized to arm A or B at 1:1 ratio as follows: * Arm A (Serplulimab): Serplulimab + chemotherapy (carboplatin-etoposide) * Arm B (control): Atezolizumab + chemotherapy (carboplatin-etoposide)

Conditions

Extensive Stage Small Cell Lung Cancer

Study Overview

Study Details

Study overview

This is a randomized, open-label study of Serplulimab plus chemotherapy (Carboplatin-Etoposide) in comparison with Atezolizumab plus chemotherapy in previously untreated US patients with ES-SCLC. Subjects in this study will be randomized to arm A or B at 1:1 ratio as follows: * Arm A (Serplulimab): Serplulimab + chemotherapy (carboplatin-etoposide) * Arm B (control): Atezolizumab + chemotherapy (carboplatin-etoposide)

A Randomized, Open-label Study of Serplulimab Plus Chemotherapy (Carboplatin-Etoposide) in Comparison With Atezolizumab Plus Chemotherapy in Previously Untreated US Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC) (ASTRIDE)

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

Condition
Extensive Stage Small Cell Lung Cancer
Intervention / Treatment

-

Contacts and Locations

Birmingham

Alabama Oncology, Birmingham, Alabama, United States, 35223

Birmingham

O'Neal Comprehensive Cancer Center, Birmingham, Alabama, United States, 352942

Goodyear

City of Hope - Phoenix, Goodyear, Arizona, United States, 85338

Tucson

Arizona Clinical Research Center (ACRC), Tucson, Arizona, United States, 85715

Springdale

Highlands Oncology Group, Springdale, Arkansas, United States, 72762

Arcadia

OPN - Oncology Physician Network, Arcadia, California, United States, 91107

Fountain Valley

Compassionate Care Research Group, Fountain Valley, California, United States, 92708

Fullerton

Providence Medical Foundation, Fullerton, California, United States, 92835

Glendale

Los Angeles Cancer Network, Glendale, California, United States, 91204

Long Beach

Long Beach Memorial Medical Center, Long Beach, California, United States, 90806

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Shanghai Henlius Biotech,

    Study Record Dates

    2025-12-31