Estimating Risk of Respiratory Infections Attributable to CFTR Heterozygosity

Description

A research team member will brush the inferior surface of the subjects' middle turbinate (nasal cavity) using a cytology brush to obtain the cells needed to perform our functional respiratory assays. An individual trained in phlebotomy will draw one 3 ml lavender top tube of blood to test c-reactive protein, calprotectin, and lactoferrin. They will also draw a 5 ml gold top serum separator tube of blood to test fibroblast growth factor-19. The participant will answer questions from the baseline survey and report their current medications interview-style with the research team member.

Conditions

Carrier State, Respiratory Infections

Study Overview

Study Details

Study overview

A research team member will brush the inferior surface of the subjects' middle turbinate (nasal cavity) using a cytology brush to obtain the cells needed to perform our functional respiratory assays. An individual trained in phlebotomy will draw one 3 ml lavender top tube of blood to test c-reactive protein, calprotectin, and lactoferrin. They will also draw a 5 ml gold top serum separator tube of blood to test fibroblast growth factor-19. The participant will answer questions from the baseline survey and report their current medications interview-style with the research team member.

Estimating the Risk for and Severity of Respiratory Infections Attributable to CFTR Heterozygosity

Estimating Risk of Respiratory Infections Attributable to CFTR Heterozygosity

Condition
Carrier State
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Previously tested and shown to be a CF carrier
  • * English-speaking
  • * Currently sick with a respiratory infection
  • * Prisoner Status
  • * Unable to provide own written, informed consent

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Philip Polgreen,

Philip M Polgreen, MD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

2024-07