A Randomized, Controlled Trial Comparing the Use of a Biodegradable Temporizing Matrix to Cadaver Skin in the Reconstruction of Hidradenitis Suppurativa Excisions

Eligibility Criteria

• 1. Is ≥18 years of age
• 2. Has presented to the Joseph M. Still Burn Center at Doctors Hospital Augusta or Advanced Wound Clinic for treatment of HS
• 3. Diagnosed with chronic Hidradenitis Suppurativa that requires a wide surgical excision in the following anatomical areas (e.g. groin, axillae, buttocks or inframammary folds)
• 4. Diagnosed with Hurley Stage 3 HS that requires wide surgical excision
• 5. Patient can still have micro-abscesses
• 6. Subject or their legally authorized representative is able to provide informed consent
• 7. Males or non-pregnant females. Females of childbearing potential (FCBP) must have a negative urine or serum pregnancy test at Baseline
• 8. Willing to comply with all study procedures and expects to be available for the duration of the study
• 9. Negative Pressure Wound Therapy is needed to stabilize and support study graft
• 1. Has a cardiac risk (NYHA Classification III)
• 2. Has active diagnosis of any autoimmune process, cancer, or organ failure that in the opinion of the investigator would prevent the subject from successfully participating in the study,
• 3. Has coagulopathy that in the opinion of the investigator, would place subject at an increased risk for bleeding.
• 4. Has a known hypersensitivity to polyurethane
• 5. Anticipates a level of non-compliance
• 6. Significant risk factors for poor wound healing
• 7. BMI \> 40