COMPLETED

Central Sodium Sensing: Implications for Blood Pressure Regulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood. The purpose of this study is to identify key sodium-sensing regions of the human brain in older adults and determine if the Na-K-2Cl co-transporter mediates the neurohumoral response to acute hypernatremia. Completion of this project will increase our understanding of blood pressure regulation, which has major public health implications.

Official Title

Central Sodium Sensing: Implications for Blood Pressure Regulation

Quick Facts

Study Start:2022-06-01

Study Completion:2025-01-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT05480722

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Age: 18 - 45 years * Blood pressure: \>100/60 mmHg and \<130/80 mmHg * BMI: 18.5 kg/m2 - 30 kg/m2 * Serum potassium: 3.5 mmol/L - 5.5 mmol/L	* Age: \< 18 years or \> 45 years * Blood pressure: \< 100/60 mmHg or \> 130/80 mmHg * BMI: \< 18.5 kg/m2 or \> 30 kg/m2 * Serum potassium: \< 3.5 mmol/L or \> 5.5 mmol/L * Abnormal ECG * History of - cardiovascular, cancer, metabolic, respiratory, renal disease * Hormone replacement therapy * Current tobacco or nicotine use * Pregnant or nursing mothers * Major brain injury (concussions do not count) * Clinically diagnosed psychiatric or neurological disorder * Clinically diagnosed anxiety or depression * Psychiatric, neurological, anxiety or depression medications * Hypertension medications * Sulfonamide drug allergy

Inclusion Criteria

Exclusion Criteria

* Age: 18 - 45 years
* Blood pressure: \>100/60 mmHg and \<130/80 mmHg
* BMI: 18.5 kg/m2 - 30 kg/m2
* Serum potassium: 3.5 mmol/L - 5.5 mmol/L

* Age: \< 18 years or \> 45 years
* Blood pressure: \< 100/60 mmHg or \> 130/80 mmHg
* BMI: \< 18.5 kg/m2 or \> 30 kg/m2
* Serum potassium: \< 3.5 mmol/L or \> 5.5 mmol/L
* Abnormal ECG
* History of - cardiovascular, cancer, metabolic, respiratory, renal disease
* Hormone replacement therapy
* Current tobacco or nicotine use
* Pregnant or nursing mothers
* Major brain injury (concussions do not count)
* Clinically diagnosed psychiatric or neurological disorder
* Clinically diagnosed anxiety or depression
* Psychiatric, neurological, anxiety or depression medications
* Hypertension medications
* Sulfonamide drug allergy

Contacts and Locations

Principal Investigator

William B Farquhar, PhD

PRINCIPAL_INVESTIGATOR

University of Delaware

Study Locations (Sites)

William B Farquhar

Newark, Delaware, 19713

United States

Collaborators and Investigators

Sponsor: University of Delaware

William B Farquhar, PhD, PRINCIPAL_INVESTIGATOR, University of Delaware

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-06-01

Study Completion Date2025-01-31

Study Record Updates

Study Start Date2022-06-01

Study Completion Date2025-01-31

Terms related to this study

Additional Relevant MeSH Terms

Salt Sensitivity of Blood Pressure