The Fuel and Rhythm (FAR) Phase 2 Study

Description

Both fuel metabolism and circadian rhythms have emerged as important targets to improve cellular and mitochondrial health and ultimately affect function in older adults. Thus, the purpose of this study is to develop minimally invasive measures that will allow us to accurately assess and detect changes in fuel metabolism and circadian rhythms in older adults following time-restricted eating.

Conditions

Aging

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Study Overview

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Study Details

Study overview

Both fuel metabolism and circadian rhythms have emerged as important targets to improve cellular and mitochondrial health and ultimately affect function in older adults. Thus, the purpose of this study is to develop minimally invasive measures that will allow us to accurately assess and detect changes in fuel metabolism and circadian rhythms in older adults following time-restricted eating.

Assessment of Fuel Utilization and Circadian Rhythms in Overweight, Older Adults Following Time Restricted Eating - Phase 2 (FAR Phase 2)

The Fuel and Rhythm (FAR) Phase 2 Study

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

Gainesville

University of Florida, Gainesville, Florida, United States, 32610

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Consent to participate in the study
  • * Men and women ≥ 65 years old
  • * Self-reported difficulty walking ¼ mile or climbing a flight of stairs
  • * Self-reported sedentariness (\<150 minutes structured exercise per week)
  • * Walking speed \<1 m/sec on the 4 m walk test
  • * Able to walk unassisted (cane allowed)
  • * Have a body mass index between 25 - 40 kg/m2 (inclusive)
  • * HbA1c \< 5.7 %
  • * Fasting \>12 hours per day
  • * Actively trying to lose weight by participating in formal weight loss program or significantly restricting calorie intake
  • * Resting heart rate of \>120 beats per minute, systolic blood pressure \> 180 mmHg and/or diastolic blood pressure of \> 100 mmHg
  • * Unstable angina, heart attack or stroke in the past 3 months
  • * Continuous use of supplemental oxygen to manage a chronic pulmonary condition or heart failure
  • * Rheumatoid arthritis, Parkinson's disease or currently on dialysis
  • * Active treatment for cancer in the past year
  • * Diabetes Mellitus
  • * Known history of skin sensitivity or allergic reaction to adhesives
  • * Taking medications that preclude fasting for 16 hours (e.g. must be taken with food at least 12 hours apart)
  • * Any condition that in the opinion of the investigator would impair ability to participate in the trial

Ages Eligible for Study

65 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Florida,

Stephen Anton, Ph.D., PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2026-03-31