The Effect of NAD Supplementation on Brain Vascular Health in Aging

Description

Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.

Conditions

Aging

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Study Overview

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Study Details

Study overview

Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.

Effects of NAD Restoration on Neurovascular Coupling in Community Dwelling Older Adults

The Effect of NAD Supplementation on Brain Vascular Health in Aging

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

Oklahoma City

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States, 73117

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥60 and ≤85 years of age
  • * Adequate hearing and visual acuity to participate in the examinations
  • * Ability to read and write in English
  • * Competence to provide informed consent.
  • * Mini-Mental State Exam score ≥24
  • * Vision or hearing impairment that would impair the ability to complete study assessments
  • * Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
  • * Cerebrovascular accident other than TIA within 60 days prior to Visit 0
  • * Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
  • * Abnormal kidney function (creatinine \>2mg/dL or EGFR \<30mL/min) by most recent labs within 6 months prior to Visit 0
  • * Elevated liver enzymes (AST and/or ALT above x2 upper limit of normal) by most recent labs within 6 months prior to Visit 0
  • * Treatment with other NAD enhancers (Nicotinamide riboside or nicotinamide mononucleotide) within 4 weeks prior to randomization.
  • * Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol

Ages Eligible for Study

60 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Oklahoma,

Andriy Yabluchanskiy, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Oklahoma

Study Record Dates

2027-12