RM1 Project 2 - tAN fMRI

Description

In this one-visit, randomized, double-blind, sham-controlled trial, we plan to use a novel concurrent transcutaneous auricular neurostimulation (tAN) paradigm during functional magnetic resonance imaging (fMRI) paradigm in 96 individuals to determine whether tAN administered to two cranial nerves simultaneously produces greater neurophysiologic effects than stimulating solely to the auricular branch of the vagus nerve (ABVN) or the auriculotemporal nerve (ATN; branch of trigeminal nerve) alone. Within the MRI scanner, each participant will be connected to a series of electrodes that stimulate 4 targets (ABVN only, ATN only, ABVN plus ATN, and Sham).

Conditions

Auricular Stimulation

Talk to us

Study Overview

On this page

Study Details

Study overview

In this one-visit, randomized, double-blind, sham-controlled trial, we plan to use a novel concurrent transcutaneous auricular neurostimulation (tAN) paradigm during functional magnetic resonance imaging (fMRI) paradigm in 96 individuals to determine whether tAN administered to two cranial nerves simultaneously produces greater neurophysiologic effects than stimulating solely to the auricular branch of the vagus nerve (ABVN) or the auriculotemporal nerve (ATN; branch of trigeminal nerve) alone. Within the MRI scanner, each participant will be connected to a series of electrodes that stimulate 4 targets (ABVN only, ATN only, ABVN plus ATN, and Sham).

Determining the Independent and Synergistic Effects of Transcutaneous Auricular Neurostimulation (tAN) on Direct Brain Activation in Healthy Individuals

RM1 Project 2 - tAN fMRI

Condition
Auricular Stimulation
Intervention / Treatment

-

Contacts and Locations

Charleston

Medical University of South Carolina Institute of Psychiatry, Charleston, South Carolina, United States, 29425

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-65
  • * Have the capacity and ability to provide one's own consent and sign the informed consent document
  • * Contraindicated for MRI.
  • * Any current or recent untreated medical, neurological, or psychiatric conditions
  • * Metal implant devices in the head, heart or neck.
  • * History of brain surgery.
  • * History of myocardial infarction or arrhythmia, bradycardia.
  • * Personal or family history of seizure or epilepsy or personal use of medications that substantially reduce seizure threshold (e.g., olanzapine, chlorpromazine, lithium).
  • * Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury.
  • * Individuals suffering from frequent/severe headaches.
  • * Individuals with a reported history of psychosis or mania, or individuals who are actively manic or psychotic.
  • * Moderate to severe alcohol or substance use disorder.
  • * Pregnancy

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Medical University of South Carolina,

Study Record Dates

2027-10-01