Imatinib TDM in GIST

Description

Imatinib can lead to long recurrence free survival in patients diagnosed with gastrointestinal stromal tumors (GIST); however side effects can significantly hinder quality of life for our patients. This study will use therapeutic drug monitoring to improve quality of life and symptoms and assess how many patients maintain therapeutic levels. Free drug levels and pharmokinetics of imatinib will also be monitored.

Conditions

Gastrointestinal Stromal Tumors

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Study Overview

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Study Details

Study overview

Imatinib can lead to long recurrence free survival in patients diagnosed with gastrointestinal stromal tumors (GIST); however side effects can significantly hinder quality of life for our patients. This study will use therapeutic drug monitoring to improve quality of life and symptoms and assess how many patients maintain therapeutic levels. Free drug levels and pharmokinetics of imatinib will also be monitored.

A Phase 2 Study of Imatinib Therapeutic Drug Monitoring in Gastrointestinal Stromal Tumor

Imatinib TDM in GIST

Condition
Gastrointestinal Stromal Tumors
Intervention / Treatment

-

Contacts and Locations

Lexington

Markey Cancer Center, Lexington, Kentucky, United States, 40536

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Histologically or cytologically confirmed GIST with KIT mutation or PDGFRA mutation (non-D842V)
  • * Currently receiving imatinib initiated within the last 3 months or to be started in the next 1 month
  • * Prior systemic chemotherapy for other malignancy is allowed as long as it was completed within the past 6 months and there is no evidence of disease
  • * Age ≥18 years
  • * ECOG performance status of 0 or 1
  • * Normal organ function
  • * Presence of PDGFRA D842V mutation
  • * Known allergy to imatinib or allergic reactions to compounds of similar chemical or biologic composition to the study drug
  • * Concomitant anticoagulation with oral warfarin.
  • * Use of strong inhibitors or inducers of CYP3A or CYP3A4, drugs metabolized by CYP3A4 or CYP2D6
  • * Uncontrolled intercurrent illness
  • * Concurrent malignancy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Reema A. Patel,

Reema Patel, MD, PRINCIPAL_INVESTIGATOR, University of Kentucky

Study Record Dates

2025-12