Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

Description

This is a prospective pilot protocol investigating whether ctDNA detection be improved by sampling the cancer draining vein versus the standard practice of sampling from a peripheral vein in patients who are undergoing biopsies for hepatobiliary and pancreatic cancers.

Conditions

Hepatobiliary Cancer, Pancreatic Cancer, Hepatocellular Carcinoma, Cholangiocarcinoma, Ampullary Cancer, Pancreatic Carcinoma

Talk to us

Study Overview

On this page

Study Details

Study overview

This is a prospective pilot protocol investigating whether ctDNA detection be improved by sampling the cancer draining vein versus the standard practice of sampling from a peripheral vein in patients who are undergoing biopsies for hepatobiliary and pancreatic cancers.

Pilot Trial Comparing Circulating Tumor DNA (ctDNA) From Immediate Draining Vein vs. Standard Peripheral Vein Sample in Patients Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

Condition
Hepatobiliary Cancer
Intervention / Treatment

-

Contacts and Locations

Orange

Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California, United States, 92868

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 years of age or older
  • * Have or are undergoing work-up for hepatobiliary and/or pancreatic carcinoma (such as hepatocellular carcinoma, cholangiocarcinoma, ampullary carcinoma, pancreatic carcinoma)
  • * Scheduled for an image-guided percutaneous or trans-jugular biopsy of a lesion
  • * Must be able to provide a written informed consent
  • * Patients unable to hold reasonably still on a procedure table or hold their breath during imaging or needle passes
  • * Patients with a gross body weight over 375 pounds (upper limit of the CT and angiography tables)
  • * Patients with uncorrectable coagulopathy
  • * Platelet count \< 30,000/ul
  • * International Normalized (INR) \> 1.5
  • * Patients with moderate to severe ascites who cannot undergo trans-jugular biopsy or sufficient drainage
  • * No clear reachable target for percutaneous or trans-jugular biopsy
  • * Patient who cannot have a peripheral blood draw for ctDNA

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Irvine,

Nadine Abi-Jaoudeh, MD, PRINCIPAL_INVESTIGATOR, Chao Family Comprehensive Cancer Center

Study Record Dates

2024-10