Exercise Reset for Concussion in a Military Environment

Description

Our primary objective is to show that early, personalized aerobic exercise treatment safely improves concussion recovery, speeds RTD, and reduces persistent symptoms in CSM. Our secondary objectives include demonstrating the clinical utility of our March-in-place test and determining fundamental mechanisms for the effect of exercise rehabilitation on concussion recovery.

Conditions

Brain Concussion

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Study Overview

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Study Details

Study overview

Our primary objective is to show that early, personalized aerobic exercise treatment safely improves concussion recovery, speeds RTD, and reduces persistent symptoms in CSM. Our secondary objectives include demonstrating the clinical utility of our March-in-place test and determining fundamental mechanisms for the effect of exercise rehabilitation on concussion recovery.

Exercise Reset for Concussion- Modifying the Buffalo Concussion Protocol for Application in a Military Environment

Exercise Reset for Concussion in a Military Environment

Condition
Brain Concussion
Intervention / Treatment

-

Contacts and Locations

Fayetteville

Fort Liberty, Fayetteville, North Carolina, United States, 28310

Jacksonville

Camp LeJeune, Jacksonville, North Carolina, United States, 28547

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged 18-40 years,
  • * Within 9 days of injury
  • * Diagnosed with concussion by an experienced clinician using standard international criteria
  • * Moderate or severe TBI as indicated by a GCS score \<13, lesion on CT/MRI, and/or focal neurologic sign consistent with intracerebral lesion
  • * Injury involving loss of consciousness for \>30 minutes or post-traumatic amnesia \>24 hours
  • * Inability to exercise because of lower-extremity orthopedic injury, clinically significant vestibular or visual dysfunction, or increased cardiac risk
  • * Pre-existing conditions that prevent participation in active testing and/or rehabilitation
  • * History of more than 3 diagnosed concussions
  • * Currently on medications that affect autonomic function, such as ADHD medication or mood stabilizers
  • * Active substance abuse/dependence
  • * Unwillingness to perform intervention
  • * Limited English proficiency.

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

State University of New York at Buffalo,

John Leddy, MD, PRINCIPAL_INVESTIGATOR, University at Buffalo

Study Record Dates

2026-03-01