RECRUITING

Benefits of Nicotinamide Riboside Upon Cognition and Sleep

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.

Official Title

The Benefits of Nicotinamide Riboside Upon Cognition and Sleep in Older Veterans

Quick Facts

Study Start:2023-04-04
Study Completion:2027-08-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05500170

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score \>5
  1. * Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score \<20

Contacts and Locations

Study Contact

Carleara Weiss, PhD, MS, RN
CONTACT
7168282006
carleara@buffalo.edu
Rebecca A Lorenz, PhD, RN
CONTACT
716-829-2204
rlorenz@buffalo.edu

Study Locations (Sites)

State University of New York at Buffalo
Buffalo, New York, 14203
United States
University at Buffalo State University of New York
Buffalo, New York, 14203
United States
Buffalo Veteran Affairs Medical Center
Buffalo, New York, 14215
United States

Collaborators and Investigators

Sponsor: State University of New York at Buffalo

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-04
Study Completion Date2027-08-30

Study Record Updates

Study Start Date2023-04-04
Study Completion Date2027-08-30

Terms related to this study

Additional Relevant MeSH Terms

  • Cognitive Impairment
  • Sleep Quality