Impact of a Prehospital Sepsis Protocol on Timely Antibiotic Administration and Subsequent Adverse Events

Description

The primary purpose of this study is to evaluate the impact of an Emergency Medical Services (EMS) based sepsis screening and early warning protocol on the timing of early sepsis care in the Emergency Department (ED).

Conditions

Sepsis

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Study Overview

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Study Details

Study overview

The primary purpose of this study is to evaluate the impact of an Emergency Medical Services (EMS) based sepsis screening and early warning protocol on the timing of early sepsis care in the Emergency Department (ED).

A Multicenter, Stepped Wedge, Cluster Randomized Study of a Prehospital Sepsis Protocol and Its Impact on Timely Antibiotic Administration in the Emergency Department and Subsequent Adverse Events

Impact of a Prehospital Sepsis Protocol on Timely Antibiotic Administration and Subsequent Adverse Events

Condition
Sepsis
Intervention / Treatment

-

Contacts and Locations

Atlanta

Emory University Hospital, Atlanta, Georgia, United States, 30322

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Saint Louis

Washington University, Saint Louis, Missouri, United States, 63130

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Lowest EMS systolic blood pressure \<110 mmHg
  • * Highest EMS pulse rate \>90 beats per minute
  • * Highest EMS respiratory rate \>20 breaths per minute
  • * EMS transport to a participating study ED/hospital
  • * At least one of the following present:
  • * Lowest systolic blood pressure \<90 mmHg
  • * Age 40 years or greater
  • * Hot temperature assessment or temp \>38 degrees Celsius
  • * Oxygen saturation \<90%
  • * Nursing home patient
  • * Emergency Medical Dispatch classification = 'sick person'
  • * Any of the following EMS conditions present:
  • * Trauma injury
  • * Cardiac arrest
  • * Psychiatric emergency
  • * Toxic ingestion
  • * Pregnant patient
  • * Inability to administratively link EMS and ED/hospital records
  • * Patient left emergency department prior to being evaluated by a medical provider (inability to classify sepsis status)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Emory University,

Carmen C Polito, MD, MSc, PRINCIPAL_INVESTIGATOR, Emory University

Jonathan E Sevransky, MD, MHS, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

2024-12