A Digital Intervention for Post-Stroke Depression and Executive Dysfunction

Eligibility Criteria

• * first-time stroke that occurred 6 months or more prior to study initiation
• * executive dysfunction as defined by a score of less than 1 standard deviation below age-adjusted normative score on at least one test of executive function in the screening assessment
• * diagnosis of Major Depressive Episode assessed by the Structured Clinical Interview for the DSM-5 (SCID).
• * at least moderate depressive symptoms as defined by Montgomery Asberg Depression Rating Scale ≥ 18
• * motor function sufficient to operate an iPad and use a pen, based on self-report and observation
• * if treated with an antidepressant medication, must be on a stable dose for a minimum of 8 weeks at the time of study enrollment.
• * able to adhere to all testing and study requirements and willingness to participate in the full study duration
• * receptive aphasia as determined by a score of 2 or 3 on the NIH Stroke Scale \[NIHSS\] item 9 ("Best Language")
• * dysarthria that makes speech unintelligible (score of 2 on NIHSS item #10)
• * severe visual impairment or hemispatial neglect (score of 3 on NIHSS item #3 or score of 2 on NIHSS item #11)
• * patient already enrolled in ongoing concurrent cognitive rehabilitation (note that if a subject is already enrolled in psychotherapy, this will not be grounds for exclusion)
• * non-fluency in English
• * presence of or history of significant neurologic or neurodegenerative disorder other than stroke
• * presence of dementia based on dependence in basic ADLs due to cognitive deficits
• * history of psychosis or mania (evaluated using the SCID).
• * active suicide ideation (assessed via the Columbia Suicide Severity Rating Scale)
• * severe executive dysfunction (based on clinical judgment during screening evaluation) precluding use of the iPad
• * severe depression-even in the absence of active suicidal ideation-based on the screening evaluation and clinical judgment of the PI, which warrants a higher level of care and/or immediate referral to psychiatric services.
• * pregnancy
• * any other clinical or medical reason in the PI's initial screening evaluation that suggests the study is not appropriate for the participant.