Characterization of the Temporo-masseteric Nerve Block (TMNB) in Healthy Subjects

Description

The proposed pilot study is aimed at preliminary characterization of the TMNB injection in 20 healthy volunteers. Assessment of bite-force distribution and surface electromyographic activity of the temporalis and the masseter muscles, at rest and clench, before and after unilateral TMNB injection, will be the primary outcome measures. Post-injection assessments will be performed at 30 minutes, 2 hours, and 2 weeks after the injection. Participants will be surveyed regarding their experience receiving the TMNB injection (secondary outcomes).

Conditions

Occlusion

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Study Overview

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Study Details

Study overview

The proposed pilot study is aimed at preliminary characterization of the TMNB injection in 20 healthy volunteers. Assessment of bite-force distribution and surface electromyographic activity of the temporalis and the masseter muscles, at rest and clench, before and after unilateral TMNB injection, will be the primary outcome measures. Post-injection assessments will be performed at 30 minutes, 2 hours, and 2 weeks after the injection. Participants will be surveyed regarding their experience receiving the TMNB injection (secondary outcomes).

Non-randomized Pilot Study to Characterize Temporo-masseteric Nerve Block (TMNB) in

Characterization of the Temporo-masseteric Nerve Block (TMNB) in Healthy Subjects

Condition
Occlusion
Intervention / Treatment

-

Contacts and Locations

Newark

Rutgers School of Dental Medicine, Newark, New Jersey, United States, 07103

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-64 years of age
  • * All ethnicity
  • * Male and female sex
  • * Fluent in written/spoken English
  • * Never been diagnosed with TMD
  • * No significant history of orofacial pain
  • * \<5 headaches/month in the 3 months before enrollment
  • * No reported use of a nightguard or occlusal splint 'No' to all questions on self-administered questionnaire for TMD screening:
  • * Pain in jaw or temple on either side of the face in the last 30 days
  • * Stiffness or pain in jaw upon awakening in the last 30 days
  • * Any pain increase/reduction in the jaw/temple region during the last 30 days with
  • * Chewing hard or tough food
  • * Opening mouth or moving jaw forward or to the side
  • * Hold teeth together/clenching/grinding/chewing gum
  • * Using the jaw during activities such as talking, kissing or yawning
  • * Traumatic injury/ surgery on face or jaw \< 6 months
  • * current orthodontic treatment
  • * pregnant or nursing,
  • * kidney failure or renal dialysis,
  • * heart disease or heart failure,
  • * uncontrolled chronic respiratory disease/ hypertension/ diabetes
  • * history of
  • * seizures
  • * hyperthyroidism
  • * drug or alcohol abuse
  • * psychiatric disorder/conditions requiring hospitalization
  • * chemotherapy/radiation

Ages Eligible for Study

18 Years to 64 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Rutgers, The State University of New Jersey,

Gayathri D Subramanian, DMD, PRINCIPAL_INVESTIGATOR, Rutgers School of Dental Medicine

Study Record Dates

2025-12