Effects of Dance and Music Appreciation on Brain Health and Fitness in People at Risk for Alzheimer's Disease

Description

The purpose of this research study is to study the effects of dance movement and music on memory and cardiorespiratory fitness in older adults who are concerned about memory loss. The study aims to determine the optimal number of movement or music appreciation classes a week to support brain health and fitness. Participants will be people 65 years or older who are concerned about their memory, but do not yet have a diagnosis of cognitive impairment. If a participant is deemed qualified to participate, he/she will be placed into one of four groups and will attend 1, 2, or 3 group or music appreciation classes per week for 24 weeks (6 months). In addition to attending the group classes, participants will be asked to complete at least four study visits at Wake Forest Baptist Medical Center to complete various clinical assessments, including a brain MRI.

Conditions

Alzheimer Disease

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Study Overview

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Study Details

Study overview

The purpose of this research study is to study the effects of dance movement and music on memory and cardiorespiratory fitness in older adults who are concerned about memory loss. The study aims to determine the optimal number of movement or music appreciation classes a week to support brain health and fitness. Participants will be people 65 years or older who are concerned about their memory, but do not yet have a diagnosis of cognitive impairment. If a participant is deemed qualified to participate, he/she will be placed into one of four groups and will attend 1, 2, or 3 group or music appreciation classes per week for 24 weeks (6 months). In addition to attending the group classes, participants will be asked to complete at least four study visits at Wake Forest Baptist Medical Center to complete various clinical assessments, including a brain MRI.

Establishing the Optimal Frequency of Dance Movement for Neurocognitive and Physical Outcomes in People at Risk of Alzheimer's Disease

Effects of Dance and Music Appreciation on Brain Health and Fitness in People at Risk for Alzheimer's Disease

Condition
Alzheimer Disease
Intervention / Treatment

-

Contacts and Locations

Winston-Salem

Wake Forest School of Medicine, Winston-Salem, North Carolina, United States, 27157

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Cognitive Change Index score ≥16
  • * Montreal Cognitive Assessment (MoCA) score ≥21
  • * Cognitively normal
  • * Low-active for past 6 months (\<30 min, 3 days/week of exercise, including walking for exercise)
  • * MRI compatible
  • * Willing and able to complete exercise testing.
  • * Has reliable transportation or is able to use transportation provided by the study.
  • * English speaking (needed for group class participation)
  • * Unable or unwilling to attend intervention classes 1-3x/week
  • * Current diagnosis of a major neurological disorder (Alzheimer's disease, Lewy body dementia, Frontotemporal dementia, Parkinson's disease, amyotrophic lateral sclerosis, etc.)
  • * Unwilling or unable to provide consent for study participation.
  • * Currently symptomatic or cortical stroke or stroke deemed exclusionary by the study physician. Reported or observed evidence of strokes on MRI will be reviewed on a case-by-case basis by the study physician to assess factors such as location, size, time since stroke, and residual symptoms.
  • * Taking medication during the intervention times that could negatively influence safety
  • * Current cancer treatment or other major medical problems that might independently affect cognition or movement or interfere with ability to attend intervention or study visits.
  • * Chronic vertigo.
  • * Enrolled in another interventional research study ≤3 months prior to beginning this study.
  • * Hip fracture, hip or knee replacement, or spinal surgery in past 6 months.
  • * Health contraindications for completing a graded exercise test and movement intervention, including uncontrolled hypertension (BP\>200/110 mmHg), hypertriglyceridemia (TG\>400 mg/dl), uncontrolled diabetes (HbA1c \> 7.5), clinical evidence of anemia.
  • * Self-reports regularly drinking \> 14 alcoholic beverages a week or current illicit drug use.
  • * Unable or unwilling to understand study procedures and comply with them for the duration of the study.

Ages Eligible for Study

65 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Wake Forest University Health Sciences,

Christina Hugenschmidt, PhD, PRINCIPAL_INVESTIGATOR, Wake Forest University Health Sciences

Study Record Dates

2027-03