Impact of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific Antigen

Description

The purpose of this study is to assess the impact of ibuprofen in men with elevated serum PSA.

Conditions

Elevated Serum PSA

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Study Overview

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Study Details

Study overview

The purpose of this study is to assess the impact of ibuprofen in men with elevated serum PSA.

Randomized Controlled Trial of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific Antigen

Impact of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific Antigen

Condition
Elevated Serum PSA
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Chicago, Chicago, Illinois, United States, 60637

Albany

Albany Medical College, Albany, New York, United States, 12208

Hershey

The Pennsylvania State University at The Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States, 17033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male patients age between 18-80 years old with a screening PSA \> 3 ng/ml being considered for additional diagnostic testing (e.g., MRI, biopsy)
  • * Normal digital rectal examination.
  • * No clinical symptoms concerning acute urinary tract infection (e.g. dysuria, malodorous urine, positive urine culture)
  • * Active urinary tract infections or bacteriuria
  • * Known prostate cancer
  • * Urethral catheter within the last 6 weeks
  • * History of hypersensitivity or allergy to ibuprofen or NSAIDs.
  • * Known severe chronic kidney disease: eGFR \< 30 mL/min/1.73 m2
  • * Known history of severe liver disease (elevated AST or ALT greater than 3 times upper limit of normal)
  • * History of gastrointestinal bleeding or NSAIDs induced GI adverse events
  • * Concomitant dual-antiplatelet use or anticoagulants
  • * Concomitant anti-inflammatory or steroidal drugs
  • * Known bleeding disorder(s)
  • * Patients with a solitary kidney or history of a kidney transplant
  • * Any other medical contraindication to NSAIDs

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Chicago,

Scott Eggener, MD, PRINCIPAL_INVESTIGATOR, University of Chicago

Study Record Dates

2025-08-01