A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Description

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

Conditions

Relapsed or Refractory Multiple Myeloma

Study Overview

Study Details

Study overview

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-1

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Condition
Relapsed or Refractory Multiple Myeloma
Intervention / Treatment

-

Contacts and Locations

Los Alamitos

Cancer and Blood Specialty Clinic, Los Alamitos, California, United States, 90720

San Diego

Sharp Memorial Hospital, San Diego, California, United States, 92123

West Hollywood

Private Practice - Dr. James R. Berenson, West Hollywood, California, United States, 90069

Aurora

Local Institution - 0381, Aurora, Colorado, United States, 80045

Farmington

Local Institution - 0380, Farmington, Connecticut, United States, 06030

Coral Springs

Advanced Research, Coral Springs, Florida, United States, 33321

Fort Myers

Local Institution - 0403, Fort Myers, Florida, United States, 33901

Saint Petersburg

Local Institution - 0401, Saint Petersburg, Florida, United States, 33705

West Palm Beach

Local Institution - 0402, West Palm Beach, Florida, United States, 33401

Athens

University Cancer Blood Ctr, Athens, Georgia, United States, 30607

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Celgene,

    Bristol-Myers Squibb, STUDY_DIRECTOR, Bristol-Myers Squibb

    Study Record Dates

    2033-11-30