Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction

Description

Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. There is some evidence that ketone ester supplements may lessen the adverse effects of sleep restriction. The main purpose of these supplements is to raise your blood concentration of ketones, which are safe, small molecules that appear in the blood during fasting, when following a ketogenic diet, or consuming ketone supplements. The main purpose of this study is to examine if ingesting a ketone ester supplement, twice daily, can improve cognitive and physical performance during short-term sleep restriction.

Conditions

Sleep Deprivation

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Study Overview

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Study Details

Study overview

Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. There is some evidence that ketone ester supplements may lessen the adverse effects of sleep restriction. The main purpose of these supplements is to raise your blood concentration of ketones, which are safe, small molecules that appear in the blood during fasting, when following a ketogenic diet, or consuming ketone supplements. The main purpose of this study is to examine if ingesting a ketone ester supplement, twice daily, can improve cognitive and physical performance during short-term sleep restriction.

Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction

Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction

Condition
Sleep Deprivation
Intervention / Treatment

-

Contacts and Locations

Columbus

The Ohio State University, Columbus, Ohio, United States, 43210

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participant is willing and able to comply with all study procedures including the following prior to Test Days: fasting (\>10 h; water only), no alcohol (\>24 h), no exercise (\>24 h), no acute illness and controlled feeding before each Test Day, maintain diet, exercise, medication, and supplement habits throughout the study.
  • * Participant has no health conditions that would prevent completion of the study requirements as judged by the Investigator based on health history.
  • * Participant understands the study procedures and signs forms providing informed consent to participate in the study and authorizes the release of relevant protected health information to the Investigator.
  • * \<18 or \>40 years of age
  • * \>35 body mass index (BMI).
  • * Diagnosed sleeping disorders (i.e., sleep apnea, insomnia).
  • * Gastrointestinal disorders or food allergies that would interfere with consuming the study supplements.
  • * Drink alcohol in excess of 3 drinks/day or 14 drinks/week
  • * Have any conditions or contraindications to blood draws.
  • * Have been diagnosed with diabetes, liver, kidney, or other metabolic or endocrine dysfunction, or use diabetic medications other than metformin
  • * Currently consume a low carbohydrate or ketogenic diet or have done so in the last 3 months
  • * Have experienced weight loss of \>10% of your body weight within the last 6 months
  • * Are pregnant, lactating, or planning on becoming pregnant during the study
  • * Have any major psychiatric disorders (e.g., schizophrenia, bipolar disorder)

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Ohio State University,

Jeff S Volek, PhD, PRINCIPAL_INVESTIGATOR, Ohio State University

Study Record Dates

2026-08