The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research. This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone, in adults following thoracic surgery. Major inpatient thoracic surgeries (TS) for lung disease are common and extremely painful surgeries and are associated with sever post-surgical pain, high incidence of chronic post-surgical pain (CPSP), excess opioid use, costly immediate postoperative opioid adverse events (AEs), and long hospital stays. This study is aiming to develop proactive risk prediction algorithms for precision surgical pain relief in adult TS patients through comparison of actual clinical outcomes with standard of care to predicted outcomes based on personalized risk assessments.
Thoracic Surgery, Pneumonectomy, Lobectomy, Segmentectomy
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research. This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone, in adults following thoracic surgery. Major inpatient thoracic surgeries (TS) for lung disease are common and extremely painful surgeries and are associated with sever post-surgical pain, high incidence of chronic post-surgical pain (CPSP), excess opioid use, costly immediate postoperative opioid adverse events (AEs), and long hospital stays. This study is aiming to develop proactive risk prediction algorithms for precision surgical pain relief in adult TS patients through comparison of actual clinical outcomes with standard of care to predicted outcomes based on personalized risk assessments.
Personalized Postoperative Pain Management Following Thoracic Surgery in Adults
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UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania, United States, 15213
UPMC Mercy Hospital, Pittsburgh, Pennsylvania, United States, 15219
UPMC Shadyside Hospital, Pittsburgh, Pennsylvania, United States, 15232
UPMC Passavant Hospital, Pittsburgh, Pennsylvania, United States, 15237
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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18 Years to 99 Years
ALL
No
OpalGenix, Inc,
Kathirvel Subramaniam, MD, MPH, PRINCIPAL_INVESTIGATOR, University of Pittsburgh
2028-03-01