Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity

Description

This study will look at whether accounting for the amount of pressure generated by the chest wall and abdomen in a obese patient, using a measurement called transpulmonary pressure, can help shorten the amount of time patients spend on the ventilator. By decreasing the amount of time patients spend on the ventilator, they are less likely to develop complications such as infections, weakness or more procedures.

Conditions

Respiratory Failure, Obesity

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Study Overview

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Study Details

Study overview

This study will look at whether accounting for the amount of pressure generated by the chest wall and abdomen in a obese patient, using a measurement called transpulmonary pressure, can help shorten the amount of time patients spend on the ventilator. By decreasing the amount of time patients spend on the ventilator, they are less likely to develop complications such as infections, weakness or more procedures.

Transpulmonary Pressure Guided Weaning From Invasive Mechanical Ventilation in Obese Patients With Respiratory Failure

Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity

Condition
Respiratory Failure
Intervention / Treatment

-

Contacts and Locations

Jackson

University of Mississippi Medical Center, Jackson, Mississippi, United States, 39216

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * on invasive mechanical ventilation for respiratory failure for \< 48 hours
  • * obese class II or higher (BMI greater than or equal to 35.0 kg/m2)
  • * contraindications to esophageal balloon catheter placement including esophageal, nasofacial, gastrointestinal abnormalities and platelets \<10,000/microliter
  • * known pleural disease such as persistent pneumothorax, pleural effusion, or pleurodesis
  • * neuromuscular disease
  • * requires chronic mechanical ventilation prior to enrollment
  • * severe neurologic injury
  • * known difficult airway
  • * life expectance is less than 48 hours

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Mississippi Medical Center,

Study Record Dates

2025-04-30