RECRUITING

Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will look at whether accounting for the amount of pressure generated by the chest wall and abdomen in a obese patient, using a measurement called transpulmonary pressure, can help shorten the amount of time patients spend on the ventilator. By decreasing the amount of time patients spend on the ventilator, they are less likely to develop complications such as infections, weakness or more procedures.

Official Title

Transpulmonary Pressure Guided Weaning From Invasive Mechanical Ventilation in Obese Patients With Respiratory Failure

Quick Facts

Study Start:2022-04-11
Study Completion:2025-04-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05530434

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * on invasive mechanical ventilation for respiratory failure for \< 48 hours
  2. * obese class II or higher (BMI greater than or equal to 35.0 kg/m2)
  1. * contraindications to esophageal balloon catheter placement including esophageal, nasofacial, gastrointestinal abnormalities and platelets \<10,000/microliter
  2. * known pleural disease such as persistent pneumothorax, pleural effusion, or pleurodesis
  3. * neuromuscular disease
  4. * requires chronic mechanical ventilation prior to enrollment
  5. * severe neurologic injury
  6. * known difficult airway
  7. * life expectance is less than 48 hours

Contacts and Locations

Study Contact

Meredith E Sloan, MD
CONTACT
601-815-9634
mesloan@umc.edu
Andrew Wilhelm, DO
CONTACT
601-984-5650
awilhelm@umc.edu

Study Locations (Sites)

University of Mississippi Medical Center
Jackson, Mississippi, 39216
United States

Collaborators and Investigators

Sponsor: University of Mississippi Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-04-11
Study Completion Date2025-04-30

Study Record Updates

Study Start Date2022-04-11
Study Completion Date2025-04-30

Terms related to this study

Keywords Provided by Researchers

  • Transpulmonary pressure
  • Respiratory failure
  • Obesity
  • Invasive mechanical ventilation

Additional Relevant MeSH Terms

  • Respiratory Failure
  • Obesity