RECRUITING

Muscle Recovery After Critical Illness

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness: 1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments 2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors 3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission

Official Title

Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical Illness

Quick Facts

Study Start:2022-10-18
Study Completion:2027-08-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05537298

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:MALE
Accepts Healthy Volunteers:Not specified
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * adult (\>18 y/o)
  2. * admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU
  1. * acute or chronic neurologic condition
  2. * acute or chronic orthopedic condition preventing strength/functional testing
  3. * patients who were not ambulatory prior to ICU admission
  4. * patients not expected to survive \~6months after admission

Contacts and Locations

Study Contact

Kirby P Mayer, PhD
CONTACT
859-218-0596
kpmaye2@uky.edu
Doug Long, MS
CONTACT
859-32-5438
delong2@uky.edu

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35005
United States
University of Kentucky
Lexington, Kentucky, 40536
United States
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, 73113
United States

Collaborators and Investigators

Sponsor: Kirby Mayer

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-10-18
Study Completion Date2027-08-01

Study Record Updates

Study Start Date2022-10-18
Study Completion Date2027-08-01

Terms related to this study

Keywords Provided by Researchers

  • skeletal muscle
  • physical function

Additional Relevant MeSH Terms

  • ICU Acquired Weakness
  • Post Intensive Care Unit Syndrome
  • Muscle Weakness
  • Critical Illness