Platelet Rich Plasma for Insufficient Endometrium

Eligibility Criteria

• * Patients who have previously undergone at least 2 unsuccessful frozen embryo transfer cycles, defined as failure to achieve a sustained clinical pregnancy (visualization of intrauterine gestational sac on ultrasound or a cancelled embryo transfer cycle due to inadequate endometrial thickness
• * Patients with a diagnosis of thin endometrial lining (less than or equal to 6 mm maximum thickness) during prior unsuccessful or canceled embryo transfer cycles.
• * Fewer than 2 prior unsuccessful or canceled frozen embryo transfer cycles.
• * Most recent unsuccessful embryo transfer prior to January 1, 2017.
• * Mullerian anomalies, excluding arcuate uterus
• * Concurrent submucosal fibroids, unrepaired uterine defects or present indication for uterine surgery
• * Communicating hydrosalpinx without plans for surgical correction prior to study enrollment.
• * Failure of patient to agree to enrollment in study with written consent.
• * Concurrent pregnancy
• * Anticoagulation use for which plasma infusion is contraindicated
• * History of thrombosis
• * Thrombophilia either inherited or acquired
• * Concomitant use of adjunctive therapies for proliferation. These must be discontinued upon enrollment.
• * Embryo planned to be used for transfer generated from surgically obtained sperm due to a diagnosis of non-obstructive azoospermia
• * Recurrent/persistent endometrial fluid in prior cycles