The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonary exacerbation: * Do participants have the same improvement in lung function and symptoms if they are treated with one type of antibiotic (called beta-lactams or β-lactams) versus taking two different types of antibiotics (tobramycin and β-lactams)? * Is taking one type of antibiotic just as good as taking two types?
Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonary exacerbation: * Do participants have the same improvement in lung function and symptoms if they are treated with one type of antibiotic (called beta-lactams or β-lactams) versus taking two different types of antibiotics (tobramycin and β-lactams)? * Is taking one type of antibiotic just as good as taking two types?
Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
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The Children's Hospital Alabama, University of Alabama at Birmingham, Birmingham, Alabama, United States, 35233
Tucson Cystic Fibrosis Center, Tucson, Arizona, United States, 85724
University of California San Diego, La Jolla, California, United States, 92093
Long Beach Memorial Medical Center, Long Beach, California, United States, 90806
CHOC Children's Hospital, Orange, California, United States, 92868
University of California at Davis Medical Center, Sacramento, California, United States, 95817
Children's National Medical Center, Washington, District of Columbia, United States, 20010
University of Florida, Gainesville, Florida, United States, 32610
Joe DiMaggio Children's Hospital, Hollywood, Florida, United States, 33021
Nemours Children's Clinic, Jacksonville, Florida, United States, 32207
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
6 Years to
ALL
No
Chris Goss,
Patrick Flume, MD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina
2026-11-15