Linezolid for Syphilis Pilot Study

Description

The study aims to evaluate the efficacy of linezolid for the treatment of syphilis.

Conditions

Syphilis

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Study Overview

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Study Details

Study overview

The study aims to evaluate the efficacy of linezolid for the treatment of syphilis.

Pilot Study of Linezolid for Early Syphilis Treatment

Linezolid for Syphilis Pilot Study

Condition
Syphilis
Intervention / Treatment

-

Contacts and Locations

Chicago

Howard Brown Health, Chicago, Illinois, United States, 60613

Jackson

Open Arms HealthCare Center, Jackson, Mississippi, United States, 39216

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 16 years of age or older
  • * Diagnosed cases of primary, secondary, or early latent syphilis with RPR titer ≥1:8 within 3 weeks prior to enrollment
  • * Able to provide informed consent
  • * For PLHIV: on treatment for HIV-infection and most recent viral load \<200 copies/mL or most recent CD4 T-cell count \>350 cells/mL
  • * Pregnancy or a positive pregnancy test on the day of enrollment
  • * Participants who receive certain psychotropic medications, e.g., MAO inhibitors, SNRIs, SSRIs
  • * Patients showing signs and symptoms of neurosyphilis
  • * Serofast RPR titer
  • * Recent (\<7 days) or concomitant antimicrobial therapy with azithromycin, doxycycline, ceftriaxone, cefixime, or other beta lactam antibiotics (e.g. amoxicillin)
  • * Linezolid or penicillin allergy

Ages Eligible for Study

16 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Southern California,

Jeffrey D Klausner, MD MPH, PRINCIPAL_INVESTIGATOR, University of Southern California

Study Record Dates

2025-03