Diabetic Foot Ulcers Microbiome and Pathogen Identification

Description

This research is being done because people with diabetes have reduced healing capacity and prone to develop infections of foot wounds. This can be problematic because wounds that become infected may result in amputation and more severe complications. New evidence suggests that a better understanding of the microbiome of wounds (e.g., bacterial presence) may provide information about wound healing and provide an earlier opportunity to identify an individual who may be prone to develop diabetic foot infection in their wound. Therefore, the purpose of this study is to evaluate the role of the microbiome of the diabetic foot ulcer in development of infection and wound healing. Once the role of the microbiome is confirmed, progress towards the prevention and treatment of diabetic foot ulcers and complications may be possible.

Conditions

Foot Ulcer, Diabetes Mellitus, Wound

Study Overview

Study Details

Study overview

This research is being done because people with diabetes have reduced healing capacity and prone to develop infections of foot wounds. This can be problematic because wounds that become infected may result in amputation and more severe complications. New evidence suggests that a better understanding of the microbiome of wounds (e.g., bacterial presence) may provide information about wound healing and provide an earlier opportunity to identify an individual who may be prone to develop diabetic foot infection in their wound. Therefore, the purpose of this study is to evaluate the role of the microbiome of the diabetic foot ulcer in development of infection and wound healing. Once the role of the microbiome is confirmed, progress towards the prevention and treatment of diabetic foot ulcers and complications may be possible.

The Role of The Microbiome in Diabetic Foot Ulcers (DFU)

Diabetic Foot Ulcers Microbiome and Pathogen Identification

Condition
Foot Ulcer
Intervention / Treatment

-

Contacts and Locations

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * DFU patients with diabetes mellitus
  • * Have a hemoglobin A1c\[HbA1c\] of 12% or less as measured within the last 6 months
  • * Stated willingness to comply with all study procedures and availability for the duration of the study
  • * Pregnant or lactating
  • * Uncontrolled blood glucose as demonstrated by by a HbA1c of greater than 12%
  • * Bilateral wound or ulcer
  • * Current infection of Coronavirus (COVID-19)
  • * Unable to provide informed consent or are unwilling to participate.

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Michigan,

Brian Schmidt, DPM, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

2026-06-01