RECRUITING

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.

Official Title

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2

Quick Facts

Study Start:2016-08-25
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05557864

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 89 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * diagnosis of idiopathic PD
  2. * have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
  3. * Existing 7T brain imagery
  1. * history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
  2. * other significant neurological disorder
  3. * history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
  4. * post-operative complications or adverse effects

Contacts and Locations

Study Contact

Colum MacKinnon, PhD
CONTACT
cmackinn@umn.edu

Study Locations (Sites)

University Of Minnesota
Minneapolis, Minnesota, 55455
United States

Collaborators and Investigators

Sponsor: University of Minnesota

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2016-08-25
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2016-08-25
Study Completion Date2025-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Parkinson's Disease