CPX-351 in Combination With Gemtuzumab Ozogamicin in Newly Diagnosed AML

Eligibility Criteria

• * Provision of signed and dated informed consent form
• * Stated willingness to comply with all study procedures and availability for the duration of the study
• * Male or female, aged ≥18 and ≤70 years with newly diagnosed any risk AML as defined by ELN 2017 criteria
• * For females of child-bearing potential: use of highly effective contraception upon enrollment and during study participation and for an additional 6 months after the end of CPX-351 and Gemtuzumab ozogamicin administration: A female of child-bearing potential is considered when a sexually mature female: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 12 consecutive months
• * The effects of CPX-351 and gemtuzumab ozogamicin on the developing human fetus are unknown. For this reason, women of child-bearing potential as defined above must have a negative serum or urine pregnancy test within 24 hours prior to beginning study treatment.
• * For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner
• * Myeloblasts expressing CD33 as determined by flow cytometry or immunohistochemistry
• * ECOG ≤ 2 and eligible to receive intensive chemotherapy as determined by the treating physician
• * Prior malignancy is allowed providing it does not require concurrent therapy. Exception: Active hormonal therapy is allowed.
• * Prior hypomethylating agents (HMA) therapy including azacitidine or decitabine when used for non-AML diagnoses is allowed. Most recent dose must have been ≥14 days prior to day 1 of study treatment.
• * Participants must have acceptable organ function
• * Adequate cardiac function defined as ejection fraction of ≥50% as determined by multigated acquisition scan (MUGA) or 2D echocardiogram.
• * Hydroxyurea is allowed for cytoreduction until day 1 of study treatment
• * Prior treatment of AML except hydroxyurea and/or leukapheresis
• * Participants with acute promyelocytic leukemia (APL).
• * Known current and clinically active central nervous system (CNS) leukemia.
• * Severe liver disease (cirrhosis, non-alcoholic steatohepatitis, sclerosing cholangitis) or patients with known Wilson's disease.
• * Participants with known active infection with hepatitis B or hepatitis C virus
• * Known allergic reactions to components of the CPX-351 (cytarabine or daunorubicin) or Gemtuzumab ozogamicin.
• * Patients with any prior anthracycline exposure plus any planned on-study anthracycline exposure cannot not exceed 550 mg/m2 of daunorubicin (or equivalent). For participants who have received radiation therapy to the mediastinum, the total cumulative dose of anthracycline should not exceed 400 mg/m2 of daunorubicin(or equivalent).
• * Hemodynamically unstable (subjects requiring vasopressor support will not be eligible).
• * Treatment with another investigational drug within 14 days.
• * Uncontrolled cardiac disease including congestive heart failure class III or IV by the NYHA, unstable angina (angina symptoms at rest), new onset angina (began within the last 3 months) or myocardial infarction within the past 6 months.
• * Any disorder that compromises the subject's ability to give written informed consent and/or to comply with study procedures.
• * Any substance abuse, severe and/or uncontrolled medical, social or psychiatric conditions that may prevent the subject from completing the study, interfere with the evaluation of safety and/or efficacy, or interfere with the interpretation of the study results.
• * Female subject who is pregnant or breastfeeding.
• * Any patient with a known FLT3 ITD or FLT3 TKD mutation