Disrupting Fear-based Memory Consolidation

Description

This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of developing post-traumatic stress disorder (PTSD). If successful, the study results would anchor a potential advance in the treatment of patients after a traumatic event and seed future animal and clinical studies of emotional sensory cortical memory consolidation to reduce the prevalence and negative sequelae of PTSD.

Conditions

Post-Traumatic Stress Disorder

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Study Overview

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Study Details

Study overview

This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of developing post-traumatic stress disorder (PTSD). If successful, the study results would anchor a potential advance in the treatment of patients after a traumatic event and seed future animal and clinical studies of emotional sensory cortical memory consolidation to reduce the prevalence and negative sequelae of PTSD.

Forgetting Fear: Establishing a Novel Non-invasive Approach to Disrupt Fear-based Sensory Memory Consolidation in Humans

Disrupting Fear-based Memory Consolidation

Condition
Post-Traumatic Stress Disorder
Intervention / Treatment

-

Contacts and Locations

Atlanta

Emory Rehabilitation Hospital, Atlanta, Georgia, United States, 30322

Atlanta

Emory University Hospital, Atlanta, Georgia, United States, 30322

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ability to provide informed consent
  • * Willingness to participate in study
  • * No history of musculoskeletal impairment or neurological disease
  • * Clinical diagnosis of PTSD for individuals in the PTSD group.
  • * Any participant outside the age range
  • * Participants that show signs of dementia (score \< 20 on the Montreal Cognitive Assessment)
  • * Participants that have a history of major head trauma, a neurodegenerative disorder, or recent (\<6 months) substance abuse;
  • * Participants that had a recent history of Central Nervous System (CNS) active drugs that may influence cortical excitability or learning; or
  • * Participants that report contraindications to TMS or MRI - if participating in the TMS/MRI experiments
  • * Current psychoactive medication usage
  • * Current symptoms of psychosis or bipolar disorder (as indicated by study staff through a clinical interview as part of that study).
  • * The study will exclude adults unable to consent, individuals who are not yet adults, pregnant women and prisoners on scientific grounds and to minimize risk.

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Emory University,

Michael Borich, PhD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

2028-12