Mandibular Advancement Device and Changes in Nocturia

Description

The main purpose of this study is to test is mandibular advacenment device (MAD) use is associated with reductions in nocturia.

Conditions

Obstructive Sleep Apnea, Nocturia, OSA

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Study Overview

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Study Details

Study overview

The main purpose of this study is to test is mandibular advacenment device (MAD) use is associated with reductions in nocturia.

Improvement in Nocturia With MAD and Changes in Polysomnographic Value

Mandibular Advancement Device and Changes in Nocturia

Condition
Obstructive Sleep Apnea
Intervention / Treatment

-

Contacts and Locations

Lexington

University of Kentucky, Lexington, Kentucky, United States, 40536

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English speaker
  • * \>18 y/o
  • * Obstructive sleep apnea diagnosis with AHI≥5
  • * ≥ 2 voiding/night at baseline
  • * Upon clinical examination ≥ 8 teeth per arch, range of mandibular protrusion ≥5 mm
  • * Consent to participate in the study.
  • * Patients with concomitant diagnosed sleep disorders (i.e. insomnia, narcolepsy, restless legs syndrome, rapid eye movement sleep behavior disorder).
  • * Prostate/kidney problems (urological disease: (eg overactive bladder, benign prostate hyperplasia)
  • * Pregnancy
  • * Heart failure, use of diuretics, diabetes, Parkinson's disease or dementia.
  • * Patients using combination therapy for the management of obstructive sleep apnea (OSA) (i.e. positive airway pressure (PAP) therapy or positional therapy).
  • * Upon clinical examination: periodontal disease (\>4 mm on periodontal probing, with bleeding on probing, visual signs of periodontal inflammation); tooth horizontal mobility \>1 mm, vertical mobility, and unfavorable crown to root ratio; open cavities, loose or fractured restorations, or patient undergoing restorative dental treatments.
  • * Exaggerated gag reflex.
  • * Lack of coordination or dexterity.
  • * Inadequate English comprehension.

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Fernanda Yanez Regonesi,

Fernanda Yanez Regonesi, DDS, MS, PRINCIPAL_INVESTIGATOR, University Of Kentucy

Study Record Dates

2025-12-01