Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia

Description

The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster randomized controlled trial with four arms: a) rapid diagnostic testing b) pharmacist-led de-escalation c) rapid diagnostic testing + pharmacist-led de-escalation and d) usual care

Conditions

Community-Acquired Pneumonia, Antimicrobial Stewardship, Point-of-Care Testing

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Study Overview

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Study Details

Study overview

The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster randomized controlled trial with four arms: a) rapid diagnostic testing b) pharmacist-led de-escalation c) rapid diagnostic testing + pharmacist-led de-escalation and d) usual care

Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia

Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia

Condition
Community-Acquired Pneumonia
Intervention / Treatment

-

Contacts and Locations

Vero Beach

Indian River Hospital, Vero Beach, Florida, United States, 32960

Weston

Weston Hospital/Cleveland Clinic Florida, Weston, Florida, United States, 33331

Akron

Akron General Hospital, Akron, Ohio, United States, 44307

Avon

Avon Hospital, Avon, Ohio, United States, 44011

Cleveland

Lutheran Hospital, Cleveland, Ohio, United States, 44113

Cleveland

Cleveland Clinic Main Campus, Cleveland, Ohio, United States, 44195

Euclid

Euclid Hospital, Euclid, Ohio, United States, 44119

Fairview Park

Fairview Hospital, Fairview Park, Ohio, United States, 44111

Garfield Heights

Marymount Hospital, Garfield Heights, Ohio, United States, 44125

Mayfield Heights

Hillcrest Hospital, Mayfield Heights, Ohio, United States, 44124

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Admission to intensive care unit within 24 hours of hospital admission
  • 2. Comfort care measures only
  • 3. Cystic fibrosis
  • 4. Discharged from an acute care hospital in the past week
  • 5. Patients not eligible for empiric therapy due to a known pathogen (any positive blood or respiratory cultures in the 72 hours prior to admission)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The Cleveland Clinic,

Michael Rothberg, M.D., PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2026-06-30