Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients

Description

In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain. Quantitative neuroimaging, radiation dose information, and directed neurocognitive testing will be acquired through this study to improve understanding of cognitive changes associated with radiation dosage to non-targeted tissue, and will provide the basis for evidence-based cognitive- sparing brain radiotherapy.

Conditions

Primary Brain Tumor, Glioma, Meningioma, Schwannoma

Study Overview

Study Details

Study overview

In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain. Quantitative neuroimaging, radiation dose information, and directed neurocognitive testing will be acquired through this study to improve understanding of cognitive changes associated with radiation dosage to non-targeted tissue, and will provide the basis for evidence-based cognitive- sparing brain radiotherapy.

Longitudinal Prospective Study of Neurocognitive Outcomes and Multimodal Quantitative Neuroimaging Outcomes in Primary Brain Tumor Patients Receiving Brain Radiotherapy

Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients

Condition
Primary Brain Tumor
Intervention / Treatment

-

Contacts and Locations

San Diego

Moores Cancer Center, San Diego, California, United States, 92037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patients 18 years or older
  • 2. Karnofsky performance status (KPS) ≥70
  • 3. Life expectancy of ≥1 year
  • 4. Primary brain tumor patients who will receive fractionated partial brain RT
  • 5. Able to complete neurocognitive assessments
  • 1. Inability to undergo MRI with contrast
  • 2. Prior brain RT

Ages Eligible for Study

18 Years to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Jona Hattangadi-Gluth,

Study Record Dates

2026-12