Natural History of Cerebral Palsy Prospective Study

Description

The study will describe the natural history of cerebral palsy (CP) as children develop over the first 2 years of life.

Conditions

Cerebral Palsy

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Study Overview

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Study Details

Study overview

The study will describe the natural history of cerebral palsy (CP) as children develop over the first 2 years of life.

Understanding the Early Natural History of Cerebral Palsy - A Prospective Cohort Study

Natural History of Cerebral Palsy Prospective Study

Condition
Cerebral Palsy
Intervention / Treatment

-

Contacts and Locations

Cincinnati

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States, 45229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Infants will be included if they have a diagnosis of CP or "at high risk of CP" and under the age of 12 months.
  • * Infants at high risk of CP as defined by any two (any combination) of the following:
  • 1. Neuroimaging predictive of a motor disability including the involvement of 1 or more of the following structures: sensori-motor cortex, Basal Ganglia, Posterior Limb of the Internal Capsule, pyramids.
  • 2. Trajectory of cramped synchronized general movements (GMs) on General Movement Assessment (GMA) OR absent fidgety GMs at fidgety age
  • 3. Hammersmith Infant Neurological Exam (HINE) scores \<57 @ 3months or \<60 @ 6months or \<63 @9 months
  • * Infants with progressive or neurodegenerative disorders or genetic disorders not associated with CP
  • * Infants with other disability diagnoses e.g. Down Syndrome

Ages Eligible for Study

3 Months to 24 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Children's Hospital Medical Center, Cincinnati,

Study Record Dates

2026-09-08