RECRUITING

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Recent studies have shown that transthyretin amyloidosis (ATTR) can sometimes cause a type of heart failure where the pumping function of the heart is normal, also known as Heart Failure with Preserved Ejection Fraction (HFpEF) or diastolic heart failure. In this single center diagnostic study, we will evaluate for ATTR in patients with HFpEF in order to to determine how frequently this occurs and how we can predict which heart failure patients may have TTR amyloidosis. Our goal is to identify amyloidosis in heart failure patients earlier so that they can start treatment.

Official Title

Prevalence and Prediction of Transthyretin Amyloidosis in Ambulatory Patients With Heart Failure With Preserved Ejection Fraction

Quick Facts

Study Start:2020-10-02
Study Completion:2024-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05577819

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients with a confirmed diagnosis of HFpEF.
  2. * Age ≥65 years old
  1. * End stage chronic kidney disease on dialysis (CKD stage 5 as defined as eGFR \<15mL/min)
  2. * no history of HFrEF (LVEF\<40%) with the exception of low LVEF in the setting of acute decompensation, AF RVR, ACS/MI, etc
  3. * Negative 99mTc-pyrophosphate scan within a year
  4. * Unable to lie down for 15 minutes for the 99mTc-pyrophosphate scan
  5. * Known diagnosis of amyloidosis
  6. * Severe valvular heart disease that is uncorrected (moderate to severe is considered exclusionary)

Contacts and Locations

Study Contact

Abbie Macher, BS
CONTACT
617-643-6328
ajmacher@mgh.harvard.edu
Laura Stockhausen, BS
CONTACT
617-724-1339
lstockhausen@mgh.harvard.edu

Principal Investigator

Hanna K Gaggin, MD
PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital

Study Locations (Sites)

Massachusetts General Hospital
Boston, Massachusetts, 02114
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Hanna K Gaggin, MD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-10-02
Study Completion Date2024-12-31

Study Record Updates

Study Start Date2020-10-02
Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

  • Transthyretin Amyloidosis
  • Heart Failure
  • Heart Failure, Diastolic
  • Amyloidosis

Additional Relevant MeSH Terms

  • Transthyretin Amyloidosis
  • Heart Failure
  • Heart Failure, Diastolic
  • Amyloidosis