Treatment of Meniere's Disease With Migraine Medications

Description

Meniere's disease (MD) is a chronic disease with a variety of fluctuating signs and symptoms, which include vertigo, hearing loss, tinnitus (ringing noise in the ear), aural pressure (feeling of ear fullness), and disequilibrium (lack of stability). Vertigo represents one of the most common and distressing problems in MD patients, and it causes various somatic and psychological disorders that interfere with the patient's quality of life. Despite the large economic and emotional impact of symptoms in MD patients, there is no FDA-approved medication to treat this debilitating condition. As such, our objective in this study is to evaluate the therapeutic potential of novel medications in treating MD that have previously shown astonishing promise in our clinical practice.

Conditions

Ménière

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Study Overview

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Study Details

Study overview

Meniere's disease (MD) is a chronic disease with a variety of fluctuating signs and symptoms, which include vertigo, hearing loss, tinnitus (ringing noise in the ear), aural pressure (feeling of ear fullness), and disequilibrium (lack of stability). Vertigo represents one of the most common and distressing problems in MD patients, and it causes various somatic and psychological disorders that interfere with the patient's quality of life. Despite the large economic and emotional impact of symptoms in MD patients, there is no FDA-approved medication to treat this debilitating condition. As such, our objective in this study is to evaluate the therapeutic potential of novel medications in treating MD that have previously shown astonishing promise in our clinical practice.

Treatment of Meniere's Disease With Nortriptyline-Topiramate Stepwise Regimen: A Randomized Double-Blinded Clinical Trial

Treatment of Meniere's Disease With Migraine Medications

Condition
Ménière
Intervention / Treatment

-

Contacts and Locations

Orange

University of California, Irvine Medical Center ENT Clinic (Pavilion 2), Orange, California, United States, 92868

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patients with active or frequent Meniere's Disease.
  • 2. Male or female between the ages of 25 to 85 years.
  • 3. Subject must be compliant with the medication and attend study visits.
  • 4. Must be able to read and write in the English language to provide consenting.
  • 1. Pregnancy will result in automatic exclusion from the study. A urine pregnancy test to rule out pregnancy for all women who are of childbearing potential.
  • 2. Subjects with history of surgery for Meniere's Disease.
  • 3. Subject with history of an adverse reaction to medication being prescribed.
  • 4. Subject suffers from a medical condition or has history that may be concerning to the investigator's clinical opinion.
  • 5. Subjects with psychosis.
  • 6. Subjects with neurological neoplasm.
  • 7. All contraindications for the medications which prevent subjects from randomization will be considered as exclusion criteria.

Ages Eligible for Study

25 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Irvine,

Hamid Djalilian, MD, PRINCIPAL_INVESTIGATOR, University of California, Irvine

Study Record Dates

2026-12-30