SUSPENDED

rTMS for Post-stroke Fatigue

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for people with post-stroke fatigue. Fatigue is a common condition after a stroke and can negatively impact an individual's ability to perform desired social and physical activities. Magnetic stimulation of the brain has been shown to improve signs and symptoms of related psychological (e.g., depression) conditions. Participants in this trial will receive a type of magnetic stimulation called repetitive magnetic stimulation, or rTMS. The investigators will measure feelings of fatigue, and other clinical characteristics related to mood and cognition, before and after participants receive rTMS.

Official Title

Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study

Quick Facts

Study Start:2023-04-10
Study Completion:2027-10-29
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:SUSPENDED

Study ID

NCT05584124

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:35 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 35 - 80 years of age
  2. * more than 6 months post-stroke
  3. * able to walk 10m unassisted
  4. * Clinically present fatigue
  1. * Contraindications to MRI/TMS/rTMS (e.g. implanted metal within the head, history of seizures)
  2. * Inability to follow simple three-step instructions
  3. * Multiple strokes on opposite hemispheres
  4. * Cerebellar and/or brainstem strokes
  5. * Diagnosed comorbid neurological conditions (e.g. multiple sclerosis, Parkinson's disease, moderate/severe TBI)
  6. * Comorbid psychological conditions (e.g. depression, anxiety, PTSD)
  7. * strokes within stimulation sites
  8. * Pregnancy
  9. * Severe hypertension (resting SBP \> 200, DBP \> 120)

Contacts and Locations

Principal Investigator

John H Kindred
PRINCIPAL_INVESTIGATOR
Ralph H. Johnson VA Medical Center, Charleston, SC

Study Locations (Sites)

Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, South Carolina, 29401-5703
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • John H Kindred, PRINCIPAL_INVESTIGATOR, Ralph H. Johnson VA Medical Center, Charleston, SC

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-10
Study Completion Date2027-10-29

Study Record Updates

Study Start Date2023-04-10
Study Completion Date2027-10-29

Terms related to this study

Keywords Provided by Researchers

  • non-invasive brain stimulation
  • post-stroke fatigue
  • perception of fatigue
  • repetitive transcranial magnetic stimulation
  • rTMS

Additional Relevant MeSH Terms

  • Stroke
  • Stroke, Chronic
  • Fatigue