rTMS for Post-stroke Fatigue

Description

This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for people with post-stroke fatigue. Fatigue is a common condition after a stroke and can negatively impact an individual's ability to perform desired social and physical activities. Magnetic stimulation of the brain has been shown to improve signs and symptoms of related psychological (e.g., depression) conditions. Participants in this trial will receive a type of magnetic stimulation called repetitive magnetic stimulation, or rTMS. The investigators will measure feelings of fatigue, and other clinical characteristics related to mood and cognition, before and after participants receive rTMS.

Conditions

Stroke, Stroke, Chronic, Fatigue

Study Overview

Study Details

Study overview

This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for people with post-stroke fatigue. Fatigue is a common condition after a stroke and can negatively impact an individual's ability to perform desired social and physical activities. Magnetic stimulation of the brain has been shown to improve signs and symptoms of related psychological (e.g., depression) conditions. Participants in this trial will receive a type of magnetic stimulation called repetitive magnetic stimulation, or rTMS. The investigators will measure feelings of fatigue, and other clinical characteristics related to mood and cognition, before and after participants receive rTMS.

Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study.

rTMS for Post-stroke Fatigue

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Charleston

Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina, United States, 29401-5703

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 35 - 80 years of age
  • * more than 6 months post-stroke
  • * able to walk 10m unassisted
  • * Clinically present fatigue
  • * Contraindications to MRI/TMS/rTMS (e.g. implanted metal within the head, history of seizures)
  • * Inability to follow simple three-step instructions
  • * Multiple strokes on opposite hemispheres
  • * Cerebellar and/or brainstem strokes
  • * Diagnosed comorbid neurological conditions (e.g. multiple sclerosis, Parkinson's disease, moderate/severe TBI)
  • * Comorbid psychological conditions (e.g. depression, anxiety, PTSD)
  • * strokes within stimulation sites
  • * Pregnancy
  • * Severe hypertension (resting SBP \> 200, DBP \> 120)

Ages Eligible for Study

35 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

John H Kindred, PRINCIPAL_INVESTIGATOR, Ralph H. Johnson VA Medical Center, Charleston, SC

Study Record Dates

2027-10-29