Mood and Thought Process Study

Description

The primary objective for this project is to test whether affective executive functioning is a mechanism of action of mindfulness-based cognitive therapy and Wellness for Wellbeing. The main questions it aims to answer are: 1. Test the effect of MBCT vs. Wellness for Wellbeing on affective inhibition (i.e., emotionally valenced inhibition as measured via the affective Go/No Go task) using an RCT. 2. Test the effect of MBCT vs. Wellness for Wellbeing on (a) affective updating and (b) affective shifting. Outcomes will be measured with the affective n-Back and the affective Internal Switching Task, respectively. 3a) The investigators will examine whether depression symptom severity co-varies with change in affective executive functioning (i.e., affecting inhibition, shifting, and updating) over time. 3b) The investigators will examine whether compliance with treatment protocol (e.g., number of classes attended, amount of home practice) predicts endpoint executive functioning. Participants will complete surveys, interviews, and computer tasks, and will be randomized to either Mindfulness-Based Cognitive Therapy or Wellness for Wellbeing.

Conditions

Depression in Remission, Depressive Symptoms, Depression

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Study Overview

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Study Details

Study overview

The primary objective for this project is to test whether affective executive functioning is a mechanism of action of mindfulness-based cognitive therapy and Wellness for Wellbeing. The main questions it aims to answer are: 1. Test the effect of MBCT vs. Wellness for Wellbeing on affective inhibition (i.e., emotionally valenced inhibition as measured via the affective Go/No Go task) using an RCT. 2. Test the effect of MBCT vs. Wellness for Wellbeing on (a) affective updating and (b) affective shifting. Outcomes will be measured with the affective n-Back and the affective Internal Switching Task, respectively. 3a) The investigators will examine whether depression symptom severity co-varies with change in affective executive functioning (i.e., affecting inhibition, shifting, and updating) over time. 3b) The investigators will examine whether compliance with treatment protocol (e.g., number of classes attended, amount of home practice) predicts endpoint executive functioning. Participants will complete surveys, interviews, and computer tasks, and will be randomized to either Mindfulness-Based Cognitive Therapy or Wellness for Wellbeing.

Affective Executive Functioning As a Mechanism of Treatments for Depression Symptoms

Mood and Thought Process Study

Condition
Depression in Remission
Intervention / Treatment

-

Contacts and Locations

Providence

Butler Hospital, Providence, Rhode Island, United States, 02906

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Adults 18 years or older
  • 2. English fluency in order to complete study procedures
  • 3. Normal vision or corrected to normal vision
  • 4. QIDS score ≥ 5 and ≤ 15 to include individuals with elevated, but not severe symptoms of depression
  • 5. No presence of psychotic symptoms that interfere with functioning
  • 6. No current hazardous alcohol or drug use
  • 7. No previous experience with mindfulness-based treatment (i.e., enrollment in MBSR or MBCT previously)
  • 8. No current symptoms of mania indicative of a manic episode
  • 9. No current cognitive impairment
  • 10. No history of a formally diagnosed learning disability in reading, intellectual disability or other developmental disorder
  • 11. No history of a neurologic illness affecting cognition
  • 12. If on psychiatric medications, no change in medications for at least 4 weeks
  • 13. If in psychotherapy, no change in therapy status for at least 4 weeks

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Butler Hospital,

Morganne Kraines, PhD, PRINCIPAL_INVESTIGATOR, Butler Hospital

Study Record Dates

2026-12