Sleep Disordered Breathing With Opioid Use

Description

There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical parameters like quality of life, sleep and pain in patients with and without opioid use. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea with opioid use. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea.

Conditions

Sleep Apnea, Opioid Use, Sleep Disordered Breathing

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Study Overview

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Study Details

Study overview

There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical parameters like quality of life, sleep and pain in patients with and without opioid use. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea with opioid use. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea.

Targeting Chemoreceptor Control of Breathing During Sleep to Mitigate Opioid-Associated Sleep Disordered Breathing

Sleep Disordered Breathing With Opioid Use

Condition
Sleep Apnea
Intervention / Treatment

-

Contacts and Locations

Detroit

John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan, United States, 48201-1916

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Veterans, age 18-89 years
  • * Veterans with prescription opioids
  • * Patients with BMI\>40kg/m2 will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control
  • * Patients with history of unresolved/untreated cardiac disease, including recent myocardial infarction, recent bypass surgery, untreated atrial and ventricular tachy-bradycardias
  • * Congestive heart failure with Cheyne-Stokes respiration (CSR)
  • * Current unstable angina
  • * Recent stroke
  • * Untreated schizophrenia
  • * Untreated hypothyroidism
  • * Unresolved seizure disorder
  • * Severe respiratory, neurological, liver and renal diseases
  • * Unstable psychiatric disorders/untreated PTSD
  • * Traumatic brain injury
  • * Pregnant women
  • * Significant sleep disorder such as narcolepsy, parasomnias disorder
  • * Failure to give informed consent
  • * Patients on tramadol and suboxone/buprenorphine

Ages Eligible for Study

18 Years to 89 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

VA Office of Research and Development,

Susmita Chowdhuri, MD MS, PRINCIPAL_INVESTIGATOR, John D. Dingell VA Medical Center, Detroit, MI

Study Record Dates

2025-12-31