RECRUITING

Comparing Antipsychotic Medications in LBD Over Time

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary objective of this study is to determine whether treatment with pimavanserin or quetiapine is associated with a greater improvement in psychosis when used in a routine clinical setting to treat hallucinations and/or delusions due to Parkinson's disease (PD) or dementia with Lewy bodies (DLB) - collectively referred to as Lewy body disease (LBD).

Official Title

A Pragmatic Randomized Trial Comparing Antipsychotics in Lewy Body Disease

Quick Facts

Study Start:2022-04-22
Study Completion:2026-02
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05590637

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients seen in the neurology clinic at UT Health San Antonio
  2. * Diagnosed with psychosis due to PD or DLB
  3. * Requiring initiation of an antipsychotic medication
  4. * Clinical equipoise between quetiapine and pimavanserin must exist
  5. * The prescribing provider must be comfortable prescribing and managing both quetiapine and pimavanserin
  1. * Medical contraindication to either medication
  2. * Caregiver unavailable to complete NPI-Q
  3. * Currently taking an antipsychotic medication
  4. * Prescribing provider unwilling to manage either medication

Contacts and Locations

Study Contact

Carolyn Paiz, BS
CONTACT
210-450-8830
paizc@uthscsa.edu

Principal Investigator

Sarah Horn, MD
PRINCIPAL_INVESTIGATOR
University of Texas Health Science Center San Antonio

Study Locations (Sites)

University Health System
San Antonio, Texas, 78229
United States
UT Health Science Center - San Antonio
San Antonio, Texas, 78229
United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center at San Antonio

  • Sarah Horn, MD, PRINCIPAL_INVESTIGATOR, University of Texas Health Science Center San Antonio

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-04-22
Study Completion Date2026-02

Study Record Updates

Study Start Date2022-04-22
Study Completion Date2026-02

Terms related to this study

Keywords Provided by Researchers

  • quetiapine
  • pimavanserin
  • psychosis
  • hallucinations
  • delusions

Additional Relevant MeSH Terms

  • Parkinson's Disease Psychosis
  • Dementia With Lewy Bodies